Vo, Hau T. and Nguyen, Ngoc-Tuyet T. and Nguyen, Hieu T. and Do, Khoa Q. and Connolly, Joseph D. and Maas, Gerhard and Heilmann, Joerg and Werz, Udo R. and Pham, Hung D. and Nguyen, Lien-Hoa D. (2012) Cytotoxic tetraoxygenated xanthones from the bark of Garcinia schomburgkiana. PHYTOCHEMISTRY LETTERS, 5 (3). pp. 553-557. ISSN 1874-3900, 1876-7486
Full text not available from this repository. (Request a copy)Abstract
Two new tetraoxygenated xanthones, 6-O-demethyloliverixanthone and schomburgxanthone, together with cowanin, cowanol, fuscaxanthones A and B, 3-isomangostin hydrate, and 1,7-dihydroxyxanthone, were isolated from the bark of Garcinia schomburgkiana. Their structures were elucidated using 1-D and 2-D NMR techniques as well as chemical methods. Five of the isolated compounds were tested regarding their cytotoxicity against HeLa cells and the results showed that fuscaxanthone B and cowanin possessed remarkable activity with IC50 values of 2.4 +/- 0.2 and 2.7 +/- 0.3 mu g/ml, respectively, using an MTT assay. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHEMICAL-CONSTITUENTS; STRUCTURE ELUCIDATION; MANGOSTANA; Garcinia schomburgkiana; Guttiferae; 6-O-Demethyloliverixanthone; Schomburgxanthone; Xanthones; Cytotoxicity |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2020 05:16 |
| Last Modified: | 07 May 2020 05:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18254 |
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