Rietschel, Liz and Streit, Fabian and Zhu, Gu and McAloney, Kerrie and Frank, Josef and Couvy-Duchesne, Baptiste and Witt, Stephanie H. and Binz, Tina M. and McGrath, John and Hickie, Ian B. and Hansell, Narelle K. and Wright, Margaret J. and Gillespie, Nathan A. and Forstner, Andreas J. and Schulze, Thomas G. and Wuest, Stefan and Nothen, Markus M. and Baumgartner, Markus R. and Walker, Brian R. and Crawford, Andrew A. and Colodro-Conde, Lucia and Medland, Sarah E. and Martin, Nicholas G. and Rietschel, Marcella (2017) Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. SCIENTIFIC REPORTS, 7: 15351. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADRENAL AXIS ACTIVITY; LONG-TERM CORTISOL; DEPRESSIVE SYMPTOMS; PERCEIVED STRESS; INTRAINDIVIDUAL STABILITY; PSYCHIATRIC-DISORDERS; SOCIOECONOMIC-STATUS; FUTURE-DIRECTIONS; MORNING CORTISOL; MAJOR DEPRESSION; |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 25 Feb 2019 15:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1853 |
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