Ramlow, Wolfgang and Roeseler, Eberhard and Heigl, Franz and Spitthoever, Ralf and Ringel, Jens and Schmitz, Gerd and Heinzler, Rainer and Abdul-Rahman, Nadim and Leistikow, Frank and Himmelsbach, Frido and Schettler, Volker and Pham, Jenny and Kozik-Jaromin, Justyna (2017) Efficacy of lipid reduction with DALI and MONET. ATHEROSCLEROSIS SUPPLEMENTS, 30. pp. 217-224. ISSN 1567-5688, 1878-5050
Full text not available from this repository. (Request a copy)Abstract
Background: Lipidapheresis techniques are increasingly used to treat drug-resistant hyperlipidemia but few efficacy studies under routine application are available. In this multicenter observational study we investigated direct adsorption of lipoproteins (DALI) and lipoprotein filtration (MONET) for the short and the long-term effects on lipid-lowering effects. Methods: Data of 122 apheresis patients from 11 centers (DALI: n = 78, MONET: n = 44) were prospectively collected for a period of 2 years. Routine lipid measurements were evaluated (2154 DALI and 1297 MONET sessions). It was investigated whether the relative reduction of LDL-C during apheresis session achieves at least 60%. Also relative reduction of total cholesterol, HDL, triglyceride, and Lp(a) were analyzed. Results: The relative reduction of LDL-C was at least 60%: DALI: 70.62%, 95% CI = [69.34; 71.90] and MONET: 64.12%, 95% CI = [60.79; 67.46]. Also triglycerides were reduced with both systems: DALI 38.63%, 95% CI = [33.95; 43.30] vs. MONET 57.68%, 95% CI = [51.91; 63.45]. Relative reductions of total cholesterol were in the range of 50% (DALI 95% CI = [46.49; 49.65] MONET 95% CI = [48.93; 55.26]) and of Lp(a) in the range of 65% (DALI 95% CI = [61.92; 65.83] MONET 95% CI = [63.71; 70.30]. HDL reduction was: DALI 15.01%, 95% CI = [13.22; 16.79] and MONET 22.59%, 95% CI = [19.33; 25.84]. For both devices treated patient plasma/blood volume and in case of DALI the use of the larger adsorber configurations (DALI 1000 and DALI 1250) were independent positive predictors of the relative reduction of LDL-C and of Lp(a). Conclusions: Both systems effectively improved lipid profile and reduced atherogenic lipids. The results point to the importance of the individualized application of these valuable therapies to achieve clinical targets. (C) 2017 Published by Elsevier Ireland Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-DENSITY-LIPOPROTEIN; LONG-TERM MULTICENTER; LDL-APHERESIS; DIRECT ADSORPTION; RISK; DALI; MONET; Lipids; Lipidapheresis; Hypercholesterolemia; Lp(a); Cholesterol |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 14 Feb 2019 09:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1888 |
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