Offenmueller, Sonja and Leiter, Ulrike and Bernbeck, Benedikt and Garbe, Claus and Eigentler, Thomas and Borkhardt, Arndt and Classen, Carl Friedrich and Corbacioglu, Selim and Dirksen, Uta and Ebetsberger-Dachs, Georg and Heinzerling, Lucie and Jorch, Norbert and Kuhlen, Michaela and Lawlor, Jennifer and Niggli, Felix and Streiter, Monika and Schneider, Dominik T. and Brecht, Ines (2017) Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP). KLINISCHE PADIATRIE, 229 (6). pp. 322-328. ISSN 0300-8630, 1439-3824
Full text not available from this repository. (Request a copy)Abstract
Background Malignant melanoma (MM) is a common malignancy in adults while it is rare in children. Thus, information on clinical behavior of pediatric MM is incomplete. Patients The German Pediatric Rare Tumor Registry (STEP) presents a prospective analysis of 60 childhood MM cases diagnosed between June 2006 and December 2014. Method Patients' ages ranged between 0 and 17 years at initial diagnosis (median age 9.6 years). Information on patient's and tumor characteristics was obtained by standardized documentation. Three-year overall survival (OS) and event-free survival (EFS) were estimated by the Kaplan-Meier test. Results Follow-up ranged from 0 to 116 months with a median of 36.5 months, however, univariate analysis was performed for 46 cases with a follow-up > 3 months, only. Cases with spitzoid histotype (40%) did not show a significantly different outcome compared to cases with non-spitzoid MM. Breslow thickness 2.00mm was identified in 30% of the cases and 18% were Clark level I to III. Adjuvant therapy was used in 45% of cases. OS at 3 years was 100%, EFS 95.2%. Conclusion We present a series of cases with a high number of spitzoid malignant melanoma and advanced pediatric melanoma, but surprisingly good overall survival rates. Spitzoid and non-spitzoid MM do not differ in clinical behavior and survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | YOUNG-ADULTS; CUTANEOUS MELANOMA; CHILDHOOD MELANOMA; SINGLE INSTITUTION; SPITZOID MELANOMA; NODE BIOPSY; CHILDREN; ADOLESCENTS; SURVIVAL; EXPERIENCE; malignant melanoma; rare pediatric tumors; pediatric oncology; German Rare Pediatric Tumor Registry; orphan disease; STEP Registry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 26 Feb 2019 08:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1918 |
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