Huang, Guozheng and Drakopoulos, Antonios and Saedtler, Marco and Zou, Huijuan and Meinel, Lorenz and Heilmann, Joerg and Decker, Michael (2017) Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27 (21). pp. 4937-4941. ISSN 0960-894X, 1464-3405
Full text not available from this repository. (Request a copy)Abstract
The alkaloid rutaecarpine and its derivatives have been described as cytotoxic and hold potential as antitumor agents. Nevertheless, their synthesis is demanding and compounds display poor water solubility. Herein, we describe the synthesis of two sets of rutaecarpine derivatives with amine functions to improve solubility. Using a classic shake-flask experiment and a potentiometric titration platform, the water solubility of the compounds was determined. Solubility improved significantly with the amine functions connected over the indole-N atom. Reduction of metabolic activity and cell viability on HeLa cells was in the same range or better for these derivatives compared to the chemically unaltered parent compounds prepared in a new synthetic procedure established in our group. (C) 2017 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MICROEMULSION SYSTEM; NATURAL-PRODUCTS; IN-VIVO; EVODIAMINE; ANALOGS; RATS; EXTRACTS; DELIVERY; AGENTS; SERUM; Rutaecarpine; SiriusT3; Cytotoxicity; Solubility |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 19 Feb 2019 13:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1940 |
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