Landgrebe, Michael and Hajak, Goeran and Wolf, Stefan and Padberg, Frank and Klupp, Philipp and Fallgatter, Andreas J. and Polak, Thomas and Hoeppner, Jacqueline and Haker, Rene and Cordes, Joachim and Klenzner, Thomas and Schoenfeldt-Lecuona, Carlos and Kammer, Thomas and Graf, Erika and Koller, Michael and Kleinjung, Tobias and Lehner, Astrid and Schecklmann, Martin and Poeppl, Timm B. and Kreuzer, Peter and Frank, Elmar and Langguth, Berthold (2017) 1-Hz rTMS in the treatment of tinnitus: A sham-controlled, randomized multicenter trial. BRAIN STIMULATION, 10 (6). pp. 1112-1120. ISSN 1935-861X, 1876-4754
Full text not available from this repository. (Request a copy)Abstract
Background: Chronic tinnitus is a frequent, difficult to treat disease with high morbidity. Objective: This multicenter randomized, sham-controlled trial investigated the efficacy and safety of 1-Hz repetitive transcranial magnetic stimulation (rTMS) applied to the left temporal cortex in patients with chronic tinnitus. Methods: Tinnitus patients were randomized to receive 10 sessions of either real or sham 1-Hz-rTMS (2000 stimuli, 110% motor threshold) to the left temporal cortex. The primary outcome was the change in the sum score of the tinnitus questionnaire (TQ) of Goebel and Hiller from baseline to end of treatment. Results: A total of 163 patients were enrolled in the study (real rTMS: 75; sham rTMS: 78). At day 12, the baseline mean of 43.1 TQ points in 71 patients assigned to real rTMS changed by -0.5 points; it changed by 0.5 points from a baseline of 42.1 in 75 patients randomized to sham rTMS (adjusted mean difference between groups: -1.0; 95.19% confidence interval: -3.2 to 1.2; p = 0.36). All secondary outcome measures including measures of depression and quality of life showed no significant differences either (p > 0.11). The number of participants with side-effects or adverse events did not differ between groups. Conclusion: Real 1-Hz-rTMS over the left temporal cortex was well tolerated but not superior compared with sham rTMS in improving tinnitus severity. These findings are in contrast to results from studies with smaller sample sizes and put the efficacy of this rTMS protocol for treatment of chronic tinnitus into question. (C) 2017 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; POSITRON-EMISSION-TOMOGRAPHY; AUDITORY-CORTEX; TEMPOROPARIETAL JUNCTION; MAJOR DEPRESSION; EFFICACY; SAFETY; PLASTICITY; INVENTORY; NETWORK; Tinnitus; Repetitive transcranial magnetic stimulation; Auditory phantom perception; RCT; Evidence-based psychiatry; Neurostimulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 19 Feb 2019 13:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1942 |
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