Osman, Shaaban K. and Brandl, Ferdinand P. and Zayed, Gamal M. and Tessmar, Joerg K. and Goepferich, Achim M. (2011) Cyclodextrin based hydrogels: Inclusion complex formation and micellization of adamantane and cholesterol grafted polymers. POLYMER, 52 (21). pp. 4806-4812. ISSN 0032-3861,
Full text not available from this repository. (Request a copy)Abstract
Inclusion complex formation between beta-cyclodextrin (beta-CD) and suitable guest molecules has frequently been exploited to design self-assembled polymer networks. In this paper, we report on hydrogels composed of eight-armed poly(ethylene glycol) (PEG) grafted with beta-CD (8armPEG20k-CD), adamantane (8armPEG20k-ad) or cholesterol (8armPEG20k-chol). Mixtures of 8armPEG20k-CD and 8armPEG20k-ad showed viscous behavior (G '' > G'); 8armPEG20k-CD and 8armPEG20k-chol formed elastic hydrogels (G' > G ''). To study the interaction of adamantane and cholesterol grafted PEG with beta-CD, linear model compounds (mPEG5k-ad and mPEG5k-chol) were synthesized. Isothermal titration calorimetry (ITC) experiments showed a higher association constant for inclusion complexes formed with mPEG5k-chol (47,000 +/- 1650) than for those formed with mPEG5k-ad (30,000 +/- 900). Fluorescence spectroscopy and dynamic light scattering (DLS) measurements further showed the ability of mPEG5k-chol to self-assemble into micelles. Self-assembly of 8armPEG20k-chol further increased the strength of the formed hydrogels. Altogether, this study contributes to a better understanding of cyclodextrin based biomaterials. (C) 2011 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BETA-CYCLODEXTRIN; AQUEOUS-SOLUTION; RHEOLOGICAL BEHAVIOR; POLY(ETHYLENE OXIDE); COPOLYMERS; STABILIZATION; NANOPARTICLES; DERIVATIVES; ACID); Hydrogels; Cyclodextrin; Isothermal titration calorimetry |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 May 2020 10:44 |
| Last Modified: | 29 May 2020 10:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20156 |
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