Staudacher, Jonas J. and Yazici, Cemal and Carroll, Timothy and Bauer, Jessica and Pang, Jingbo and Krett, Nancy and Xia, Yinglin and Wilson, Annette and Papachristou, Georgios and Dirmeier, Andrea and Kunst, Claudia and Whitcomb, David C. and Fantuzzi, Giamila and Jung, Barbara (2017) Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target. SCIENTIFIC REPORTS, 7: 12786. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Acute Pancreatitis is a substantial health care challenge with increasing incidence. Patients who develop severe disease have considerable mortality. Currently, no reliable predictive marker to identify patients at risk for severe disease exists. Treatment is limited to rehydration and supporting care suggesting an urgent need to develop novel approaches to improve standard care. Activin is a critical modulator of inflammatory responses, but has not been assessed in pancreatitis. Here, we demonstrate that serum activin is elevated and strongly correlates with disease severity in two established murine models of acute pancreatitis induced by either cerulein or IL-12 + IL-18. Furthermore, in mice, inhibition of activin conveys survival benefits in pancreatitis. In addition, serum activin levels were measured from a retrospective clinical cohort of pancreatitis patients and high activin levels in patients at admission are predictive of worse outcomes, indicated by longer overall hospital and intensive care unit stays. Taken together, activin is a novel candidate as a clinical marker to identify those acute pancreatitis patients with severe disease who would benefit from aggressive treatment and activin may be a therapeutic target in severe acute pancreatitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC INFLAMMATION; UNITED-STATES; COLON-CANCER; FOLLISTATIN; MICE; DISEASE; MANAGEMENT; OBESE; INTERLEUKIN-18; PATHOGENESIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 25 Feb 2019 15:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2023 |
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