Balduzzi, A. and Dalle, J-H and Jahnukainen, K. and von Wolff, M. and Lucchini, G. and Ifversen, M. and Macklon, K. T. and Poirot, C. and Diesch, T. and Jarisch, A. and Bresters, D. and Yaniv, I. and Gibson, B. and Willasch, A. M. and Fadini, R. and Ferrari, L. and Lawitschka, A. and Ahler, A. and Saenger, N. and Corbacioglu, S. and Ansari, M. and Moffat, R. and Dalissier, A. and Beohou, E. and Sedlacek, P. and Lankester, A. and Rubio, C. D. De Heredia and Vettenranta, K. and Wachowiak, J. and Yesilipek, A. and Trigoso, E. and Klingebiel, T. and Peters, C. and Bader, P. (2017) Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group. BONE MARROW TRANSPLANTATION, 52 (10). pp. 1406-1415. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Fertility preservation is an urgent challenge in the transplant setting. A panel of transplanters and fertility specialists within the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the International BFM Study Group provides specific guidelines. Patients and families should be informed of possible gender-and age-specific cryopreservation strategies that should be tailored according to the underlying disease, clinical condition and previous exposure to chemotherapy. Semen collection should be routinely offered to all postpubertal boys at the diagnosis of any disease requiring therapy that could potentially impair fertility. Testicular tissue collection might be offered to postpubertal boys; nevertheless, its use has been unsuccessful to date. Oocyte collection after hormonal hyperstimulation should be offered to postpubertal girls facing gonadotoxic therapies that could be delayed for the 2 weeks required for the procedure. Ovarian tissue collection could be offered to pre-/post-pubertal girls. Pregnancies have been reported after postpubertal ovarian tissue reimplantation; however, to date, no pregnancy has been reported after the reimplantation of prepubertal ovarian tissue or in vitro maturation of pre-/post-pubertal ovarian tissue. Possible future advances in reproductive medicine could change this scenario. Health authorities should prioritize fertility preservation projects in pediatric transplantation to improve patient care and quality of life.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CRYOPRESERVED OVARIAN TISSUE; ANTI-MULLERIAN HORMONE; ACUTE LYMPHOBLASTIC-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; CHRONIC MYELOID-LEUKEMIA; FEMALE CANCER-PATIENTS; TESTICULAR TISSUE; CLINICAL-PRACTICE; CHRONIC GVHD; LIVE BIRTH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 25 Feb 2019 15:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2069 |
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