Posavec, Damir and Dorsch, Andre and Bogner, Udo and Bernhardt, Guenther and Nagl, Stefan (2011) Polyvinyl butyral nanobeads: preparation, characterization, biocompatibility and cancer cell uptake. MICROCHIMICA ACTA, 173 (3-4). pp. 391-399. ISSN 0026-3672,
Full text not available from this repository. (Request a copy)Abstract
We describe the synthesis of spherical poly(vinyl butyral) (PVB) nanobeads by controlled precipitation via addition of non-solvent. Effects of various reaction parameters on nanoparticle size were investigated by dynamic light scattering and electron microscopy. The ability to incorporate dopant molecules was studied using a fluorescent perylene derivative as a model additive, and the dye-doped nanoparticles were investigated by confocal microscopy. In an optimized experimental protocol, PVB nanoparticles were obtained that were efficiently taken up by human cancer cells devoid of coating. The novel nanospheres are economic, easy to prepare and capable of incorporating additives. Lacking cytotoxicity in vitro, PVB nanobeads are attractive with respect to various potential applications such as optical imaging and particle tracking, diagnostics, and drug delivery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DRUG-DELIVERY; NANOPARTICLES; PARTICLES; OXYGEN; Polyvinyl butyral; Nanoparticles; Fluorescent microbeads; Live cell imaging; Cytotoxicity |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jun 2020 14:16 |
| Last Modified: | 15 Jun 2020 14:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/20785 |
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