Pathophysiology of GvHD and Other HSCT-Related Major Complications

Ghimire, Sakhila and Weber, Daniela and Mavin, Emily and Wang, Xiao Nong and Dickinson, Anne Mary and Holler, Ernst (2017) Pathophysiology of GvHD and Other HSCT-Related Major Complications. FRONTIERS IN IMMUNOLOGY, 8: 79. ISSN 1664-3224

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Abstract

For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve patient quality of life, and yet, complete success is hard to achieve. This review assimilates recent updates on pathophysiology of GvHD, prophylaxis and treatment of GvHD-related complications, and advances in the potential treatment of GvHD.

Item Type: Article
Uncontrolled Keywords: VERSUS-HOST-DISEASE; STEM-CELL TRANSPLANTATION; REGULATORY T-CELLS; BONE-MARROW-TRANSPLANTATION; MINOR HISTOCOMPATIBILITY ANTIGENS; TOTAL-BODY IRRADIATION; CONSENSUS DEVELOPMENT PROJECT; CLINICAL-TRIALS NETWORK; WORKING GROUP-REPORT; UNRELATED DONORS; pathophysiology; graft versus host disease; T cells; haematopoietic stem cell transplantation; prophylaxis
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Depositing User: Petra Gürster
Date Deposited: 14 Dec 2018 13:00
Last Modified: 04 Sep 2020 06:50
URI: https://pred.uni-regensburg.de/id/eprint/209

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