Neuenhahn, M. and Albrecht, J. and Odendahl, M. and Schlott, F. and Doessinger, G. and Schiemann, M. and Lakshmipathi, S. and Martin, K. and Bunjes, D. and Harsdorf, S. and Weissinger, E. M. and Menzel, H. and Verbeek, M. and Uharek, L. and Kroeger, N. and Wagner, E. and Kobbe, G. and Schroeder, T. and Schmitt, M. and Held, G. and Herr, W. and Germeroth, L. and Bonig, H. and Tonn, T. and Einsele, H. and Busch, D. H. and Grigoleit, G. U. (2017) Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT. LEUKEMIA, 31 (10). pp. 2161-2171. ISSN 0887-6924, 1476-5551
Full text not available from this repository. (Request a copy)Abstract
Cytomegalovirus (CMV) infection is a common, potentially life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). We assessed prospectively the safety and efficacy of stem cell-donor-or third-party-donor-derived CMV-specific T cells for the treatment of persistent CMV infections after allo-HSCT in a phase I/IIa trial. Allo-HSCT patients with drugrefractory CMV infection and lacking virus-specific T cells were treated with a single dose of ex vivo major histocompatibility complex-Streptamer-isolated CMV epitope-specific donor T cells. Forty-four allo-HSCT patients receiving a T-cell-replete (D+ repl; n = 28) or T-cell-depleted (D+ depl; n = 16) graft from a CMV-seropositive donor were screened for CMV-specific T-cell immunity. Eight D+ depl recipients received adoptive T-cell therapy from their stem cell donor. CMV epitope-specific T cells were well supported and became detectable in all treated patients. Complete and partial virological response rates were 62.5% and 25%, respectively. Owing to longsome third-party donor (TPD) identification, only 8 of the 57 CMV patients transplanted from CMV-seronegative donors (D-) received antigen-specific T cells from partially human leukocyte antigen (HLA)-matched TPDs. In all but one, TPD-derived CMV-specific T cells remained undetectable. In summary, adoptive transfer correlated with functional virus-specific T-cell reconstitution in D+ depl patients. Suboptimal HLA match may counteract expansion of TPD-derived virus-specific T cells in D-patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADOPTIVE TRANSFER; CYTOMEGALOVIRUS DISEASE; TRANSPLANTATION; RECONSTITUTION; IMMUNITY; RECIPIENTS; THERAPY; IMMUNOTHERAPY; MULTICENTER; LYMPHOCYTES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 25 Feb 2019 15:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2101 |
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