Delacher, Michael and Imbusch, Charles D. and Weichenhan, Dieter and Breiling, Achim and Hotz-Wagenblatt, Agnes and Traeger, Ulrike and Hofer, Ann-Cathrin and Kaegebein, Danny and Wang, Qi and Frauhammer, Felix and Mallm, Jan-Philipp and Bauer, Katharina and Herrmann, Carl and Lang, Philipp A. and Brors, Benedikt and Plass, Christoph and Feuerer, Markus (2017) Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. NATURE IMMUNOLOGY, 18 (10). 1160-+. ISSN 1529-2908, 1529-2916
Full text not available from this repository. (Request a copy)Abstract
Regulatory T cells (T-reg cells) perform two distinct functions: they maintain self-tolerance, and they support organ homeostasis by differentiating into specialized tissue T-reg cells. We found that epigenetic modifications defined the molecular characteristics of tissue T-reg cells. Tagmentation-based whole-genome bisulfite sequencing revealed more than 11,000 regions that were methylated differentially in pairwise comparisons of tissue T-reg cell populations and lymphoid T cells. Similarities in the epigenetic landscape led to the identification of a common tissue T-reg cell population that was present in many organs and was characterized by gain and loss of DNA methylation that included many gene sites associated with the T(H)2 subset of helper T cells, such as the gene encoding cytokine IL-33 receptor ST2, as well as the production of tissue-regenerative factors. Furthermore, the ST2-expressing population was dependent on the transcriptional regulator BATF and could be expanded by IL-33. Thus, tissue T-reg cells integrate multiple waves of epigenetic reprogramming that define their tissue-restricted specialization.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRIPTION FACTOR OCCUPANCY; ADIPOSE-TISSUE; CANNABINOID RECEPTOR; READ ALIGNMENT; IMMUNE-SYSTEM; INFLAMMATION; MACROPHAGE; POPULATION; VISUALIZATION; ACCUMULATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 25 Feb 2019 15:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2128 |
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