Szczepanowski, Monika and Lange, Jonas and Kohler, Christian W. and Masque-Soler, Neus and Zimmermann, Martin and Aukema, Sietse M. and Altenbuchinger, Michael and Rehberg, Thorsten and Mahn, Friederike and Siebert, Reiner and Spang, Rainer and Burkhardt, Birgit and Klapper, Wolfram (2017) Cell-of-origin classification by gene expression and MYC-rearrangements in diffuse large B-cell lymphoma of children and adolescents. BRITISH JOURNAL OF HAEMATOLOGY, 179 (1). pp. 116-119. ISSN 0007-1048, 1365-2141
Full text not available from this repository. (Request a copy)Abstract
We present the largest series of diffuse large B-cell lymphoma (DLBCL) in patients younger than 18 years analysed to date by gene expression profiling using Nanostring technology to identify molecular subtypes and fluorescent in situ hybridization for translocations of MYC. We show that the activated B cell-like subtype of DLBCL is exceedingly rare in children and - in contrast to adults-not associated with outcome. Furthermore, we review the current literature and demonstrate that MYC translocations are not more frequent in paediatric compared to adult DLBCL. A prognostic role of MYC in the paediatric age groups seems unlikely.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; digital multiplexed gene expression profiling; nCounter; diffuse large B-cell lymphoma; children; adolescents |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 13 Feb 2019 12:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2131 |
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