Wood, Christian M. and Nicolas, Celine S. and Choi, Sun-Lim and Roman, Erika and Nylander, Ingrid and Fernandez-Teruel, Alberto and Kiianmaa, Kalervo and Bienkowski, Przemyslaw and de Jong, Trynke R. and Colombo, Giancarlo and Chastagnier, Denis and Wafford, Keith A. and Collingridge, Graham L. and Wildt, Sheryl J. and Conway-Campbell, Becky L. and Robinson, Emma S. J. and Lodge, David (2017) Prevalence and influence of cys407*Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour. NEUROPHARMACOLOGY, 115. pp. 128-138. ISSN 0028-3908, 1873-7064
Full text not available from this repository. (Request a copy)Abstract
Modulation of metabotropic glutamate 2 (mGlu2) receptor function has huge potential for treating psychiatric and neurological diseases. Development of drugs acting on mGlu2 receptors depends on the development and use of translatable animal models of disease. We report here a stop codon mutation at cysteine 407 in Grm2 (cys407*) that is common in some Wistar rats. Therefore, researchers in this field need to be aware of strains with this mutation. Our genotypic survey found widespread prevalence of the mutation in commercial Wistar strains, particularly those known as Han Wistar. Such Han Wistar rats are ideal for research into the separate roles of mGlu2 and mG1u3 receptors in CNS function. Previous investigations, unknowingly using such mGlu2 receptor-lacking rats, provide insights into the role of mGlu2 receptors in behaviour. The Grm2 mutant rats, which dominate some selectively bred lines, display characteristics of altered emotionality, impulsivity and risk-related behaviours and increased voluntary alcohol intake compared with their mGlu2 receptor-competent counterparts. In addition, the data further emphasize the potential therapeutic role of mGlu2 receptors in psychiatric and neurological disease, and indicate novel methods of studying the role of mGlu2 and mGlu3 receptors. This article is part of the Special Issue entitled 'Metabotropic Glutamate Receptors, 5 years on'. (C) 2016 The Authors. Published by Elsevier Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METABOTROPIC GLUTAMATE RECEPTORS; NUCLEUS-ACCUMBENS SHELL; LOW-(RLA) AVOIDANCE RATS; FEAR-POTENTIATED STARTLE; GENETIC ABSENCE EPILEPSY; ANXIETY-RELATED BEHAVIOR; HIGH-PREFERRING WHP; AVOIDING ANA RATS; STRESS RESPONSES; PHENOTYPIC CHARACTERIZATION; Metabotropic glutamate receptor; mGlu2; Grm2 mutation; Wistar rats; Han Wistar rats; Emotionality; Anxiety; Selectively bred rats; Alcohol preference |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 615 Pharmacy |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:00 |
| Last Modified: | 04 Sep 2020 06:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/215 |
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