Gakis, Georgios and Morgan, Todd M. and Efstathiou, Jason A. and Keegan, Kirk A. and Mischinger, Johannes and Todenhoefer, Tilman and Schubert, Tina and Zaid, Harras B. and Hrbacek, Jan and Ali-El-Dein, Bedeir and Clayman, Rebecca H. and Galland, Sigolene and Olugbade, Kola and Rink, Michael and Fritsche, Hans-Martin and Burger, Maximilian and Chang, Sam S. and Babjuk, Marko and Thalmann, George N. and Stenzl, Arnulf and Daneshmand, Siamak (2016) Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma. WORLD JOURNAL OF UROLOGY, 34 (1). pp. 97-103. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
Purpose To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC). Methods A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. Results Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026). Conclusions These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Clinical; Nodal stage; Primary urethral carcinoma; Prognostic; Risk factors; Survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2019 12:36 |
| Last Modified: | 07 Mar 2019 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2208 |
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