Harris, Andrew C. and Young, Rachel and Devine, Steven and Hogan, William J. and Ayuk, Francis and Bunworasate, Udomsak and Chanswangphuwana, Chantiya and Efebera, Yvonne A. and Holler, Ernst and Litzow, Mark and Ordemann, Rainer and Qayed, Muna and Renteria, Anne S. and Reshef, Ran and Woelfl, Matthias and Chen, Yi-Bin and Goldstein, Steven and Jagasia, Madan and Locatelli, Franco and Mielke, Stephan and Porter, David and Schechter, Tal and Shekhovtsova, Zhanna and Ferrara, James L. M. and Levine, John E. (2016) International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 22 (1). pp. 4-10. ISSN 1083-8791, 1523-6536
Full text not available from this repository. (Request a copy)Abstract
Acute graft-versus-host disease (GVHD) remains a leading cause of morbidity and nonrelapse mortality after allogeneic hematopoietic cell transplantation. The clinical staging of GVHD varies greatly between transplant centers and is frequently not agreed on by independent reviewers. The lack of standardized approaches to handle common sources of discrepancy in GVHD grading likely contributes to why promising GVHD treatments reported from single centers have failed to show benefit in randomized multicenter clinical trials. We developed guidelines through international expert consensus opinion to standardize the diagnosis and clinical staging of GVHD for use in a large international GVHD research consortium. During the first year of use, the guidance followed discussion of complex clinical phenotypes by experienced transplant physicians and data managers. These guidelines increase the uniformity of GVHD symptom capture, which may improve the reproducibility of GVHD clinical trials after further prospective validation. (C) 2016 American Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEMATOPOIETIC-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; SURVIVAL; THERAPY; MORTALITY; DIAGNOSIS; CENTERS; SCORE; Bone marrow transplant; BMT; Graft-versus-host disease; Guidance; Guidelines; GVHD; staging; standardization |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2019 12:36 |
| Last Modified: | 07 Mar 2019 09:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2222 |
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