Dollinger, Marco and Zeman, Florian and Niessen, Christoph and Lang, Sven A. and Beyer, Lukas P. and Mueller, Martina and Stroszczynski, Christian and Wiggermann, Philipp (2016) Bile Duct Injury after Irreversible Electroporation of Hepatic Malignancies: Evaluation of MR Imaging Findings and Laboratory Values. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 27 (1). pp. 96-103. ISSN 1051-0443, 1535-7732
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Purpose: To evaluate biliary complications after irreversible electroporation (IRE) of hepatic malignancies. Materials and Methods: hi 24 patients (11 men; mean age, 59.3 y), bile ducts were located within a 1.0-cm radius of the ablation zone at subacute follow-up (ie, 1-3 4) after percutaneous IRE of 53 hepatic tumors (primary hepatic tumors, n = 14). MR. imaging, conducted with a hepatocyte-specific contrast agent before and after treatment, was examined for evidence of bile duct injury. Serum bilirubin and alkaline phosphatase levels measured at subacute and short-term follow-up (ie, 1-2 mo after IRE) were analyzed for evidence of biliary injury. Correlations between bile duct injury and characteristics of patients, lesions, and ablation procedures were assessed by generalized linear Models. Results: Fifty-five bile acts were located within 1.0 cm of an ablation defect. Locations relative to the ablation area were as follows: 33 were encased, 14 were abutting, and 8 were located within a radius of 0.1-1.0 cm of the ablation zone. Subacute follow-up MR images showed 15 bile duct injuries (narrowing, n = 8; dilation, n = 7). At subacute follow-up, three patients showed transient abnormalities of laboratory values (bilirubin, 1.6-5.2 mg/dL). Short-term laboratory values were abnormal in one patient (increase in alkaline phosphatase of 533 U/L vs baseline) as a result of local tumor recurrence. Patient age (continuous, P = .026; < 65 y vs >= 65 y, P = .001) was independently associated with post-IRE bile duct injury. Conclusions: Bile ducts adjacent to an IRE ablation area remain largely unaffected by this procedure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ABLATION; LIVER; TUMORS; |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2019 12:36 |
| Last Modified: | 07 Mar 2019 09:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2227 |
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