Granata, Cesare and Oliveira, Rodrigo S. F. and Little, Jonathan P. and Renner, Kathrin and Bishop, David J. (2017) Sprint-interval but not continuous exercise increases PGC-1 alpha protein content and p53 phosphorylation in nuclear fractions of human skeletal muscle. SCIENTIFIC REPORTS, 7: 44227. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Sprint interval training has been reported to induce similar or greater mitochondrial adaptations to continuous training. However, there is limited knowledge about the effects of different exercise types on the early molecular events regulating mitochondrial biogenesis. Therefore, we compared the effects of continuous and sprint interval exercise on key regulatory proteins linked to mitochondrial biogenesis in subcellular fractions of human skeletal muscle. Nineteen men, performed either 24 min of moderate-intensity continuous cycling at 63% of W-Peak (CE), or 4 x 30-s "all-out" cycling sprints (SIE). Muscle samples (vastus lateralis) were collected pre-, immediately (+0 h) and 3 (+3 h) hours postexercise. Nuclear p53 and PHF20 protein content increased at +0 h, with no difference between groups. Nuclear p53 phosphorylation and PGC-1 alpha protein content increased at +0 h after SIE, but not CE. We demonstrate an exercise-induced increase in nuclear p53 protein content, an event that may relate to greater p53 stability - as also suggested by increased PHF20 protein content. Increased nuclear p53 phosphorylation and PGC-1 alpha protein content immediately following SIE but not CE suggests these may represent important early molecular events in the exercise-induced response to exercise, and that SIE is a time-efficient and possibly superior option than CE to promote these adaptations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-INTENSITY INTERVAL; TUMOR-SUPPRESSOR PROTEIN; MITOCHONDRIAL BIOGENESIS; MESSENGER-RNA; PRESCRIBING EXERCISE; LOW-VOLUME; EXPRESSION; AMPK; ADAPTATIONS; RESPIRATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:00 |
| Last Modified: | 25 Feb 2019 11:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/223 |
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