Clara, Renan Orsati and Assmann, Nadine and Ramos Moreno, Ana Carolina and Coimbra, Janine Baptista and Nurenberger, Nadine and Dettmer-Wilde, Katja and Oefner, Peter Josef and Campa, Ana (2016) Melanocytes are more responsive to IFN-gamma and produce higher amounts of kynurenine than melanoma cells. BIOLOGICAL CHEMISTRY, 397 (1). pp. 85-90. ISSN 1431-6730, 1437-4315
Full text not available from this repository. (Request a copy)Abstract
A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-gamma plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-gamma. In general, IFN-gamma affected KP in skin cells more than in melanoma cells, supporting IFN-gamma roles in skin physiology and that of stromal cells in modulating the tumor microenvironment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARYL-HYDROCARBON RECEPTOR; 3-HYDROXYANTHRANILIC ACID; TRYPTOPHAN-METABOLITES; QUINOLINIC ACID; CANCER; RADIATION; SKIN; interferon-gamma; melanocytes; melanoma; metabolism; tryptophan |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2019 12:36 |
| Last Modified: | 11 Mar 2019 12:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2259 |
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