Proske, Judith and Walter, Lisa and Bumes, Elisabeth and Hutterer, Markus and Vollmann-Zwerenz, Arabel and Eyuepoglu, Ilker Y. and Savaskan, Nicolai E. and Seliger, Corinna and Hau, Peter and Uhl, Martin (2016) Adaptive Immune Response to and Survival Effect of Temozolomide- and Valproic Acid-induced Autophagy in Glioblastoma. ANTICANCER RESEARCH, 36 (3). pp. 899-905. ISSN 0250-7005, 1791-7530
Full text not available from this repository. (Request a copy)Abstract
Background/Aim: The combination of radiotherapy, temozolomide and valproic acid (VPA) has shown some promise in retrospective analyses of patients with glioblastoma, although their mechanisms of action remain unknown. Materials and Methods: We investigated the in vitro and in vivo effects of pretreating glioma cells with temozolomide and VPA as an immunization strategy to boost an adaptive immune response in a syngeneic mouse model. Results: Temozolomide and VPA induced autophagy in GL261 glioma cells, and caused tumor antigen-specific T-cells to become activated effector T-cells. Mice with a pre-existing glioma showed no improvement in clinical outcome when immunized with temozolomide-and VPA-treated glioma cells. Conclusion: Although temozolomide and VPA treatment of glioma cells can boost the adaptive immune response, in the context of a vaccine therapy, additional factors are necessary to eradicate the tumor and improve survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD8(+) T-CELLS; ADJUVANT TEMOZOLOMIDE; GLIOMA-CELLS; TRIAL; CHEMOTHERAPY; DEATH; RADIOTHERAPY; CONCOMITANT; MULTIFORME; RADIATION; Temozolomide; valproic acid; autophagy; glioblastoma; dendritic cells; CD8 T-cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Mar 2019 12:38 |
| Last Modified: | 11 Mar 2019 12:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2275 |
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