Schebesch, Karl-Michael and Brawanski, Alexander and Hohenberger, Christoph and Hoehne, Julius (2016) Fluorescein Sodium-Guided Surgery of Malignant Brain Tumors: History, Current Concepts, and Future Projects. TURKISH NEUROSURGERY, 26 (2). pp. 185-194. ISSN 1019-5149
Full text not available from this repository. (Request a copy)Abstract
Fluorescein sodium (FL)-guided resection has become an important and beneficial treatment method for malignant brain tumors. FL-guided resection improves the rate of gross total resection in high-grade gliomas (HGG) and cerebral metastases (CM). FL sensitively visualizes the disruption of the blood-brain barrier in the area surrounding malignant lesions, similar to contrast-enhanced T1-weighted MR sequences. This review of the current literature summarizes the history of FL in neurosurgery from 1946 until today. We discuss the molecular mechanism of FL accumulation in cerebral malignant tumors and provide an overview of the current practice of using FL and applying a dedicated surgical microscope filter. Additionally, we outline and discuss ongoing trials and future projects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-GRADE GLIOMAS; SURGICAL MICROSCOPE FILTER; GLIOBLASTOMA-MULTIFORME; CEREBRAL METASTASES; TECHNICAL NOTE; INTRAOPERATIVE FLUORESCENCE; 5-AMINOLEVULINIC ACID; TOTAL RESECTION; A FEASIBILITY; BLOOD-BRAIN; Fluorescence-guided surgery; Fluorescein sodium; High-grade glioma; Cerebral metastases; YELLOW 560 nm filter; Malignant brain tumor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 03 Sep 2020 07:00 |
| Last Modified: | 03 Sep 2020 07:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2320 |
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