Hummel, Irena Brunskole and Huber, Barbara and Wenzel, Juergen J. and Jilg, Wolfgang (2016) Markers of Protection in Children and Adolescents Six to Fourteen Years After Primary Hepatitis B Vaccination in Real Life A Pilot Study. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 35 (3). pp. 286-291. ISSN 0891-3668, 1532-0987
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Background: Not many data are available on long-term immunity against hepatitis B (HB) for children vaccinated under real-life conditions. Methods: Two hundred and thirty-two children and adolescents vaccinated 6-14 years earlier in pediatric practices were examined for conditions of vaccination and markers of protection as anti-HBs, anamnestic response to a booster dose and cell-mediated immunity. Results: Fifty-six percent of the participants were vaccinated according to the German vaccination recommendations (group 1). In 44.0% (group 2), these recommendations were not followed. Anti-HBs concentrations of >= 10 IU/L were found in 53.1% of group 1 and 45.1% of group 2 participants. A booster dose resulted in 91 of 99 participants in having an anamnestic response, in 3 (5.9%) of group 1 and 5 (10.4%) of group 2 anti-HBs remained below 10 IU/L. In group 1, postbooster anti-HBs concentration was inversely correlated with time since the last vaccination. Cellular immune responses were seen in only 5% of revaccinated individuals before the booster, increasing to 30% thereafter. Conclusions: Under real-life conditions about half of vaccinees have lost protecting antibodies 6-14 years after vaccination in infancy, but in approximately 90% of them, immune memory was demonstrated. However, as memory may wane, revaccination at a time when boostability is still present might be considered.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURFACE-ANTIGEN; VIRUS INFECTION; ANTIBODY-RESPONSE; IMMUNE-RESPONSES; BOOSTER; INFANCY; MEMORY; IMMUNOGENICITY; IMMUNIZATION; PERSISTENCE; children; hepatitis B; long-term immunity; real-life study; infants; vaccination |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2019 06:36 |
| Last Modified: | 12 Mar 2019 06:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2332 |
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