Bumes, Elisabeth and Rzonsa, Sarah and Hutterer, Markus and Proescholdt, Martin and Bogdahn, Ulrich and Riemenschneider, Markus J. and Uhl, Martin and Wendl, Christina and Hau, Peter (2016) Adverse event grading following CTCAE v3.0 underestimates hypertensive side effects in patients with glioma treated with Bevacizumab. JOURNAL OF NEURO-ONCOLOGY, 127 (1). pp. 191-200. ISSN 0167-594X, 1573-7373
Full text not available from this repository. (Request a copy)Abstract
Anti-VEGF therapy with Bevacizumab (BEV) is widely used in cases of relapsed high-grade glioma (HGG). Arterial hypertension is a known side effect of anti-VEGF therapy. 42 Patients with relapsed HGG were treated with BEV 10 mg/kg on days 1 and 15 of 28-day cycles in addition to treatment with 40 mg TMZ daily until disease progression, based on magnetic resonance imaging and/or worsening of clinical status. In a retrospective analysis, hypertensive side effects were evaluated as the primary endpoint, while survival information in addition to toxicity was analyzed as secondary endpoint. Grading which employs the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 detected hypertensive events with a significantly higher sensitivity than CTCAE version 3.0. The rate of severe hypertensive events observed as CTCAE >= degrees 3 were 9.5 % in version 3.0 and 45.2 % in version 4.0. The results presented here indicate that CTCAE version 3.0 may underreport the incidence and grade of BEV-induced hypertension within clinical trials. As hypertension has not only long-term, but also severe short-term side effects, we suggest that arterial hypertension under BEV should be scored according to CTCAE version 4.0 to avoid clinically relevant hypertension-related adverse events in these patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SINGLE-AGENT BEVACIZUMAB; PHASE-II TRIAL; NEWLY-DIAGNOSED GLIOBLASTOMA; RECURRENT MALIGNANT GLIOMA; RADIATION-THERAPY; METRONOMIC CHEMOTHERAPY; DAILY TEMOZOLOMIDE; PLUS IRINOTECAN; PROGRESSION; MULTIFORME; Glioblastoma; High-grade glioma; Bevacizumab; Temozolomide; Hypertension; CTCAE |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2019 07:56 |
| Last Modified: | 12 Mar 2019 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2338 |
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