Lehner, Astrid and Schecklmann, Martin and Greenlee, Mark W. and Rupprecht, Rainer and Langguth, Berthold (2016) Triple-site rTMS for the treatment of chronic tinnitus: a randomized controlled trial. SCIENTIFIC REPORTS, 6: 22302. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Recent research indicates that tinnitus is related to alterations of neural networks including temporal, parietal, and prefrontal brain regions. The current study examines a rTMS protocol which targets three central nodes of these networks in a two-arm randomized parallel group trial. Overall, 49 patients with chronic tinnitus were randomized to receive either triple-site stimulation (left dorsolateral prefrontal stimulation, 1000 pulses, 20 Hz plus left and right temporoparietal stimulation, 1000 pulses each, 1 Hz) or single-site stimulation (left temporoparietal stimulation, 3000 pulses, 1 Hz). Both groups were treated in ten sessions. Tinnitus severity as measured by the tinnitus questionnaire was assessed before rTMS (day1), after rTMS (day12) and at two follow-up visits (day 90 and day 180). The triple-site protocol was well tolerated. There was a significant reduction in tinnitus severity for both treatment groups. The triple-site group tended to show a more pronounced treatment effect at day 90. However, the measurement time point x group interaction effect was not significant. The current results confirm former studies that indicated a significant reduction of tinnitus severity after rTMS treatment. No significant superiority of the multisite protocol was observed. Future approaches for the enhancement of treatment effects are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; MULTISITE RTMS; DEPRESSION; QUESTIONNAIRE; DISTRESS; CORTEX; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Mar 2019 14:10 |
| Last Modified: | 11 Mar 2019 14:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2360 |
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