Kunzelmann, Karl and Cabrita, Ines and Wanitchakool, Podchanart and Ousingsawat, Jiraporn and Sirianant, Lalida and Benedetto, Roberta and Schreiber, Rainer (2016) Modulating Ca2+ signals: a common theme for TMEM16, Ist2, and TMC. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468 (3). pp. 475-490. ISSN 0031-6768, 1432-2013
Full text not available from this repository. (Request a copy)Abstract
Since the discovery of TMEM16A (anoctamin 1, ANO1) as Ca2+-activated Cl- channel, the protein was found to serve different physiological functions, depending on the type of tissue. Subsequent reports on other members of the anoctamin family demonstrated a broad range of yet poorly understood properties. Compromised anoctamin function is causing a wide range of diseases, such as hearing loss (ANO2), bleeding disorder (ANO6), ataxia and dystonia (ANO3, 10), persistent borrelia and mycobacteria infection (ANO10), skeletal syndromes like gnathodiaphyseal dysplasia and limb girdle muscle dystrophy (ANO5), and cancer (ANO1, 6, 7). Animal models demonstrate CF-like airway disease, asthma, and intestinal hyposecretion (ANO1). Although present data indicate that ANO1 is a Ca2+-activated Cl- channel, it remains unclear whether all anoctamins form plasma membrane-localized or intracellular chloride channels. We find Ca2+-activated Cl- currents appearing by expression of most anoctamin paralogs, including the Nectria haematococca homologue nhTMEM16 and the yeast homologue Ist2. As recent studies show a role of anoctamins, Ist2, and the related transmembrane channel-like (TMC) proteins for intracellular Ca2+ signaling, we will discuss the role of these proteins in generating compartmentalized Ca2+ signals, which may give a hint as to the broad range of cellular functions of anoctamins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CA2+-ACTIVATED CL-CHANNEL; ACTIVATED CHLORIDE CHANNEL; AIRWAY SMOOTH-MUSCLE; GASTROINTESTINAL STROMAL TUMORS; VOMERONASAL SENSORY NEURONS; DISTAL MUSCULAR-DYSTROPHY; REGULATED ANION CHANNEL; ANOCTAMIN 5 MUTATIONS; GNATHODIAPHYSEAL-DYSPLASIA; TRANSMEMBRANE PROTEIN; TMEM16 proteins; Anoctamin 1; Anoctamin 6; TMEM16A; TMEM16F; TMC; nhTMEM16; Ca2+ signaling; Ist2; Lipid rafts; ER Ca2+ store; SCP2; Secretion |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann |
| Depositing User: | Petra Gürster |
| Date Deposited: | 03 Sep 2020 06:47 |
| Last Modified: | 03 Sep 2020 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2368 |
Actions (login required)
 |
View Item |
