Schwantes-An, Tae-Hwi and Zhang, Juan and Chen, Li-Shiun and Hartz, Sarah M. and Culverhouse, Robert C. and Chen, Xiangning and Coon, Hilary and Frank, Josef and Kamens, Helen M. and Konte, Bettina and Kovanen, Leena and Latvala, Antti and Legrand, Lisa N. and Maher, Brion S. and Melroy, Whitney E. and Nelson, Elliot C. and Reid, Mark W. and Robinson, Jason D. and Shen, Pei-Hong and Yang, Bao-Zhu and Andrews, Judy A. and Aveyard, Paul and Beltcheva, Olga and Brown, Sandra A. and Cannon, Dale S. and Cichon, Sven and Corley, Robin P. and Dahmen, Norbert and Degenhardt, Louisa and Foroud, Tatiana and Gaebel, Wolfgang and Giegling, Ina and Glatt, Stephen J. and Grucza, Richard A. and Hardin, Jill and Hartmann, Annette M. and Heath, Andrew C. and Herms, Stefan and Hodgkinson, Colin A. and Hoffmann, Per and Hops, Hyman and Huizinga, David and Ising, Marcus and Johnson, Eric O. and Johnstone, Elaine and Kaneva, Radka P. and Kendler, Kenneth S. and Kiefer, Falk and Kranzler, Henry R. and Krauter, Ken S. and Levran, Orna and Lucae, Susanne and Lynskey, Michael T. and Maier, Wolfgang and Mann, Karl and Martin, Nicholas G. and Mattheisen, Manuel and Montgomery, Grant W. and Mueller-Myhsok, Bertram and Murphy, Michael F. and Neale, Michael C. and Nikolov, Momchil A. and Nishita, Denise and Noethen, Markus M. and Nurnberger, John and Partonen, Timo and Pergadia, Michele L. and Reynolds, Maureen and Ridinger, Monika and Rose, Richard J. and Rouvinen-Lagerstrom, Noora and Scherbaum, Norbert and Schmael, Christine and Soyka, Michael and Stallings, Michael C. and Steffens, Michael and Treutlein, Jens and Tsuang, Ming and Wall, Tamara L. and Wodarz, Norbert and Yuferov, Vadim and Zill, Peter and Bergen, Andrew W. and Chen, Jingchun and Cinciripini, Paul M. and Edenberg, Howard J. and Ehringer, Marissa A. and Ferrell, Robert E. and Gelernter, Joel and Goldman, David and Hewitt, John K. and Hopfer, Christian J. and Iacono, William G. and Kaprio, Jaakko and Kreek, Mary Jeanne and Kremensky, Ivo M. and Madden, Pamela A. F. and McGue, Matt and Munafo, Marcus R. and Philibert, Robert A. and Rietschel, Marcella and Roy, Alec and Rujescu, Dan and Saarikoski, Sirkku T. and Swan, Gary E. and Todorov, Alexandre A. and Vanyukov, Michael M. and Weiss, Robert B. and Bierut, Laura J. and Saccone, Nancy L. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. BEHAVIOR GENETICS, 46 (2). pp. 151-169. ISSN 0001-8244, 1573-3297
Full text not available from this repository. (Request a copy)Abstract
The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human genetic studies of addiction. Because of its potential functional significance, the non-synonymous variant rs1799971 (A118G, Asn40Asp) in OPRM1 has been extensively studied, yet its role in addiction has remained unclear, with conflicting association findings. To resolve the question of what effect, if any, rs1799971 has on substance dependence risk, we conducted collaborative meta-analyses of 25 datasets with over 28,000 European-ancestry subjects. We investigated non-specific risk for "general" substance dependence, comparing cases dependent on any substance to controls who were non-dependent on all assessed substances. We also examined five specific substance dependence diagnoses: DSM-IV alcohol, opioid, cannabis, and cocaine dependence, and nicotine dependence defined by the proxy of heavy/light smoking (cigarettes-per-day > 20 vs. a parts per thousand currency sign10). The G allele showed a modest protective effect on general substance dependence (OR = 0.90, 95 % C.I. [0.83-0.97], p value = 0.0095, N = 16,908). We observed similar effects for each individual substance, although these were not statistically significant, likely because of reduced sample sizes. We conclude that rs1799971 contributes to mechanisms of addiction liability that are shared across different addictive substances. This project highlights the benefits of examining addictive behaviors collectively and the power of collaborative data sharing and meta-analyses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MU-OPIOID-RECEPTOR; GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISM; FAMILY-BASED ASSOCIATION; QUANTITATIVE TRAIT LOCI; MINNESOTA TWIN FAMILY; ALCOHOL DEPENDENCE; NICOTINE DEPENDENCE; GENE OPRM1; SMOKING-CESSATION; Addiction; Substance dependence; OPRM1; Opioid receptor; Single nucleotide polymorphism (SNP); Genetic association |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2019 07:10 |
| Last Modified: | 12 Mar 2019 07:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2371 |
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