Ditz, Diana and Rabanus, Robert and Schulz, Christian and Wolff, Daniel and Holler, Barbara and Holler, Ernst and Hildebrandt, Gerhard Carl (2016) The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation. CROATIAN MEDICAL JOURNAL, 57 (1). pp. 16-28. ISSN 0353-9504, 1332-8166
Full text not available from this repository. (Request a copy)Abstract
Aim To retrospectively assess if the modified lung function score (LFS) and/or its components, forced expiratory volume within the first second (FEV1) and diffusion capacity for carbon monoxide corrected for hemoglobin level (cDLCO), predict overall survival (OS) and chronic graft-vs-host-disease (cGvHD). Methods We evaluated 241 patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the University of Regensburg Transplant Center between June 1998 and July 2005 in relation to their LFS, FEV1 and cDLCO, before and after HSCT. Results Decreased OS after allo-HSCT was related to decreased pre-transplantation values of FEV1 < 60% (P = 0.040), cDLCO<50% of predicted value (P = 0.025), and LFS >= III (P = 0.037). It was also related to decreased FEV1 at 3 and 12 months after HSCT (P < 0.001 and P = 0.001, respectively) and increased LFS at 3 and 12 months after HSCT (P = 0.028 and P = 0.002, respectively), but not to changes of cDLCO. A higher incidence of cGvHD was related to decreased FEV1 at 6, 12, and 18 months (P = 0.069, P = 0.054, and P = 0.009, respectively) and increased LFS at 12 months (P = 0.002), but not to changes in cDLCO. Conclusions OS was related to both LFS and FEV1, but cGvHD had a stronger relation to FEV1 than to cDLCO or LFS. FEV1 alone offered more information on the outcome after allo-HSCT than LFS or cDLCO, suggesting limited value of LFS for the patients' assessment after allo-HSCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONSENSUS DEVELOPMENT PROJECT; BONE-MARROW-TRANSPLANTATION; WORKING GROUP-REPORT; NONINFECTIOUS PULMONARY COMPLICATIONS; LONG-TERM SURVIVORS; MEASURING THERAPEUTIC RESPONSE; QUALITY-OF-LIFE; BRONCHIOLITIS-OBLITERANS; CLINICAL-TRIALS; RISK-FACTORS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2019 13:07 |
| Last Modified: | 12 Mar 2019 13:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2431 |
Actions (login required)
 |
View Item |
