Markus, Marcello Ricardo Paulista and Meffert, Peter J. and Baumeister, Sebastian Edgar and Lieb, Wolfgang and Siewert, Ulrike and Schipf, Sabine and Koch, Manja and Kors, Jan A. and Felix, Stephan Burkhard and Doerr, Marcus and Targher, Giovanni and Voelzke, Henry (2016) Association between hepatic steatosis and serum liver enzyme levels with atrial fibrillation in the general population The Study of Health in Pomerania (SHIP). ATHEROSCLEROSIS, 245. pp. 123-131. ISSN 0021-9150, 1879-1484
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Background: Hepatic steatosis (HS) affects up to 35% of adults in the general population. Atrial fibrillation (AF) is the most prevalent sustained arrhythmia and has a substantial impact on healthcare costs. We analyzed cross-sectional associations of HS and serum liver enzyme levels with prevalent AF in a general population sample. Methods: We analyzed data from 3090 women and men, aged 20-81 years, from the population-based Study of Health in Pomerania. HS was determined by ultrasonography. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (GGT) were measured photometrically. AF was determined by automatic electrocardiographic analysis software. Results: The prevalences of HS and AF were 30.3% and 1.49%, respectively. ALT, AST and GGT showed a positive linear association with the risk of prevalent AF, after multivariable adjustment. The adjusted odds ratios for AF per 1-standard deviation increment in log-transformed serum liver enzyme levels were 1.65 (95% confidence interval [CI]: 1.16 to 2.35; p = 0.006) for ALT, 1.47 (95% CI: 1.07 to 2.02; p = 0.017) for AST and 2.17 (95% CI: 1.64 to 2.87; p < 0.001) for GGT. In contrast, ultrasonographic HS was not associated with AF. Conclusions: Our findings indicate that moderately elevated serum liver enzymes, but not sonographic liver hyperechogenicity, were associated with increased AF prevalence in the general adult population. The hepatic release of increased levels of serum liver enzymes might be accompanied by higher levels of
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEFT-VENTRICULAR HYPERTROPHY; CARDIOVASCULAR-DISEASE; PERICARDIAL FAT; VALVE SCLEROSIS; RISK; HEART; ATHEROSCLEROSIS; EPIDEMIOLOGY; INFLAMMATION; COMBINATION; Atrial fibrillation; Hepatic steatosis; Liver enzymes; Non-alcoholic fatty liver disease; Population-based study; Risk factors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2019 09:34 |
| Last Modified: | 14 Mar 2019 09:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2485 |
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