Brandl, Ferdinand and Hammer, Nadine and Blunk, Torsten and Tessmar, Joerg and Goepferich, Achim (2010) Biodegradable Hydrogels for Time-Controlled Release of Tethered Peptides or Proteins. BIOMACROMOLECULES, 11 (2). pp. 496-504. ISSN 1525-7797, 1526-4602
Full text not available from this repository.Abstract
Tethering drug substances to it gel network is all effective way of controlling the release kinetics of hydrogel-based drug delivery systems Here, we report oil in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization of branched poly(ethylene glycol). The gel strength ranged from 1075 to 2435 Pit: the degradation time varied between 24 and 120 h. Fluorescence recovery after photobleaching showed that fluorescently labeled bovine serum albumin (FITC-BSA) was Successfully bound to the gel network during gel formation Within 168 h, the mobility of the tethered molecules gradually increased due to polymer degradation Using FITC-BSA and lysozyme as model proteins, we showed the potential of the developed hydrogels for time-controlled release. The obtained release profiles had a sigmoidal shape and matched the degradation profile very well. protein release wits complete after 96 h
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMS EMPLOYING 1,6-ELIMINATION; DRUG-DELIVERY; MODEL; HYDROLYSIS; DIFFUSION; ACYLATION; DESIGN; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Aug 2020 09:30 |
| Last Modified: | 07 Aug 2020 09:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25175 |
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