Emmrich, Thomas and El-Tayeb, Ali and Taha, Hesham and Seifert, Roland and Mueller, Christa E. and Link, Andreas (2010) Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20 (1). pp. 232-235. ISSN 0960-894X, 1464-3405
Full text not available from this repository. (Request a copy)Abstract
(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3-hydroxy-4-[2-(methylamino)benzamido]tetrahydrofuran-2-yl-methoxy[(hydroxy) phosphoryloxy][(hydroxy) phosphoryl]dichloromethylphosphonic acid was synthesized as a chemically and metabolically stable analog of ATP substituted with a fluorescent methylanthranoyl (MANT) residue. The compound is intended for studying the binding site and function of adenylyl cyclases (ACs), which was exemplified by studying its interaction with Bacillus anthracis edema factor(EF) AC exotoxin. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EDEMA FACTOR; INHIBITORS; TOXIN; NUCLEOTIDES; DERIVATIVES; RECEPTORS; PURINE; Adenylyl cyclase; MANT-nucleotide; Fluorescent-label; Triphosphate analog |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Aug 2020 08:45 |
| Last Modified: | 12 Aug 2020 08:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25373 |
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