Alberter, Barbara and Klein, Christoph A. and Polzer, Bernhard (2016) Single-cell analysis of CTCs with diagnostic precision: opportunities and challenges for personalized medicine. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 16 (1). pp. 25-38. ISSN 1473-7159, 1744-8352
Full text not available from this repository. (Request a copy)Abstract
The generation of variant cancer cells is the major cause of acquired resistance against systemic therapies and consequently, of our inability to cure advanced cancer patients. Circulating tumor cells are gaining increasing clinical attention because they may enable the monitoring cancer progression and adjustment of treatment. In recent years multiple technologies for enrichment, isolation as well as molecular and functional analysis of circulating tumor cells have been developed. Implementation of these technologies in standardized and automated workflows in clinical diagnostics could provide valuable information for real-time monitoring of cancer and eventually new therapeutic strategies for the benefit of patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIRCULATING TUMOR-CELLS; METASTATIC BREAST-CANCER; MULTIPLE DISPLACEMENT AMPLIFICATION; RESISTANT PROSTATE-CANCER; LUNG-CANCER; MOLECULAR CHARACTERIZATION; PERIPHERAL-BLOOD; PROGNOSTIC-SIGNIFICANCE; BRANCHED EVOLUTION; COLORECTAL-CANCER; circulating tumor cells; liquid biopsy; whole genome amplification; molecular single-cell analysis; CTC cultivation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für experimentelle Medizin und Therapieverfahren |
| Depositing User: | Petra Gürster |
| Date Deposited: | 03 Sep 2020 05:52 |
| Last Modified: | 03 Sep 2020 05:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2563 |
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