Barro-Soria, Rene and Caicedo, Alejandro and Jaegle, Herbert and Merkel, Laura and Zhao, Na and Knop, Gabriel and Gierke, Kaspar and Dannullis, Andrea and Castrop, Hayo and Brandstaetter, Johann Helmut and Kirchhoff, Frank and Feigenspan, Andreas and Strauss, Olaf (2019) Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells. SCIENTIFIC REPORTS, 9: 19622. ISSN 2045-2322,
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Fast, precise and sustained neurotransmission requires graded Ca2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca2+ fluxes and Ca2+ buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-receptor-associated protein (ATRAP) localizes to synaptic terminals throughout the central nervous system. In the retinal photoreceptor synapse and the cerebellar mossy fiber-granule cell synapse, we find that ATRAP is involved in the generation of depolarization-evoked synaptic Ca2+ transients. Compared to wild type, Ca2+ imaging in acutely isolated preparations of the retina and the cerebellum from ATRAP knockout mice reveals a significant reduction of the sarcoendoplasmic reticulum (SR) Ca2+-ATPase (SERCA) activity. Thus, in addition to its conventional role in angiotensin signaling, ATRAP also modulates presynaptic Ca2+ signaling within the central nervous system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRESYNAPTIC CALCIUM STORES; SYNAPTIC-TRANSMISSION; BLOOD-PRESSURE; ROD; ATRAP; EXPRESSION; IDENTIFICATION; RELEASE; SITES; HOMEOSTASIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Biology, Preclinical Medicine > Institut für Physiologie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 06:48 |
| Last Modified: | 20 Mar 2020 06:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25657 |
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