Kunz, Joachim B. and Lobitz, Stephan and Grosse, Regine and Oevermann, Lena and Hakimeh, Dani and Jarisch, Andrea and Cario, Holger and Beier, Rita and Schenk, Daniela and Schneider, Dominik and Gross-Wieltsch, Ute and Prokop, Aram and Heine, Sabine and Khurana, Claudia and Erlacher, Miriam and Duerken, Matthias and Linke, Christina and Fruehwald, Michael and Corbacioglu, Selim and Claviez, Alexander and Metzler, Markus and Ebinger, Martin and Full, Hermann and Wiesel, Thomas and Eberl, Wolfgang and Reinhard, Harald and Tagliaferri, Laura and Allard, Pierre and Karapanagiotou-Schenkel, Irini and Rother, Lisa-Marie and Beck, Dorothea and Le Cornet, Lucian and Kulozik, Andreas E. (2020) Sickle cell disease in Germany: Results from a national registry. PEDIATRIC BLOOD & CANCER, 67 (4): e28130. ISSN 1545-5009, 1545-5017
Full text not available from this repository. (Request a copy)Abstract
Background Limited data on the prevalence and medical care of sickle cell disease (SCD) in Germany are available. Here, we make use of a patient registry to characterize the burden of disease and the treatment modalities for patients with SCD in Germany. Procedure A nationwide German registry for patients with SCD documents basic data on diagnosis and patient history retrospectively at the time of registration. A prospective annual documentation provides more details on complications and treatment of SCD. For the current analyses, data of 439 patients were available. Results Most patients had homozygous SCD (HbSS 75.1%, HbS/beta-thalassemia 13.2%, and HbSC 11.3%). The median age at diagnosis was 1.9 years (interquartile range, 0.6-4.4 years), most patients were diagnosed when characteristic symptoms occurred. Sepsis and stroke had affected 3.2% and 4.2% of patients, respectively. During the first year of observation, 48.3% of patients were admitted to a hospital and 10.1% required intensive care. Prophylactic penicillin was prescribed to 95.6% of patients with homozygous SCD or HbS/beta thalassemia below the age of six and hydroxycarbamide to 90.4% of patients above the age of two years. At least one annual transcranial Doppler ultrasound was documented for 74.8% of patients between 2 and 18 years. Conclusion With an estimated number of at least 2000, the prevalence of SCD in Germany remains low. Prospectively, we expect that the quality of care for children with SCD will be further improved by an earlier diagnosis after the anticipated introduction of a newborn screening program for SCD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHILDREN; HYDROXYUREA; PREVENTION; ANEMIA; MANAGEMENT; MORTALITY; SURVIVAL; STROKE; COHORT; epidemiology; Germany; registry; sickle cell disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Apr 2020 09:54 |
| Last Modified: | 07 Apr 2020 09:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25660 |
Actions (login required)
 |
View Item |
