Schroeder, Agnes and Neubert, Patrick and Titze, Jens and Bozec, Aline and Neuhofer, Wolfgang and Proff, Peter and Kirschneck, Christian and Jantsch, Jonathan (2019) Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5. JCI INSIGHT, 4 (23): e127868. ISSN 2379-3708
Full text not available from this repository. (Request a copy)Abstract
Dietary salt consumption leads to cutaneous Na+ storage and is associated with various disorders, including osteopenia. Here, we explore the impact of Na+ and the osmoprotective transcription factor nuclear factor of activated T cell 5 (NFAT5) on bone density and osteoclastogenesis. Compared with treatment of mice with high-salt diet, low-salt diet (LSD) increased bone density, decreased osteoclast numbers, and elevated Na+ content and Nfat5 levels in the BM. This response to LSD was dependent on NFAT5 expressed in myeloid cells. Simulating in vivo findings, we exposed osteoclast precursors and osteoblasts to elevated Na+ content (high-salt conditions; HS cent), resulting in increased NFAT5 binding to the promotor region of RANKL decoy receptor osteoprotegerin (OPG). These data not only demonstrate that NFAT5 in myeloid cells determines the Na+ content in BM, but that NFAT5 is able to govern the expression of the osteoprotective gene OPG. This provides insights into mechanisms of Na+-induced cessation of osteoclastogenesis and offers potentially new targets for treating salt-induced osteopenia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SODIUM-CHLORIDE; OSTEOCLAST DIFFERENTIATION; ELECTROLYTE HOMEOSTASIS; ANTIBACTERIAL DEFENSE; PHOSPHATE-TRANSPORT; BLOOD-PRESSURE; BONE; CALCIUM; LIGAND; NA+; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2020 08:17 |
| Last Modified: | 20 Mar 2020 08:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25687 |
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