Markowiak, Till and Kerner, Nadine and Neu, Reiner and Potzger, Tobias and Grosser, Christian and Zeman, Florian and Hofmann, Hans-Stefan and Ried, Michael (2019) Adequate nephroprotection reduces renal complications after hyperthermic intrathoracic chemotherapy. JOURNAL OF SURGICAL ONCOLOGY, 120 (7). pp. 1220-1226. ISSN 0022-4790, 1096-9098
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Background and Objectives Hyperthermic intrathoracic chemotherapy (HITOC) is used for the treatment of malignant pleural tumors. Although HITOC proved to be safe, postoperative renal failure due to nephrotoxicity of intrapleural cisplatin remains a concern. Methods This single-center study was performed retrospectively in patients who underwent pleural tumor resection and HITOC between September 2008 and December 2018. Results A total of 84 patients (female n = 33; 39.3%) with malignant pleural tumors underwent surgical cytoreduction with subsequent HITOC (60 minutes; 42 degrees C). During the study period, we gradually increased the dosage of cisplatin (100-150 mg/m(2) BSA n = 36; 175 mg/m(2) BSA n = 2) and finally added doxorubicin (cisplatin 175 mg/m(2) BSA/doxorubicin 65 mg; n = 46). All patients had perioperative fluid balancing. The last 54 (64.3%) patients also received perioperative cytoprotection. Overall 29 patients (34.5%) experienced renal insufficiency. Despite higher cisplatin concentrations, patients with cytoprotection showed significantly lower postoperative serum creatinine levels after 1 week (P = .006) and at discharge (P = .020). Also, they showed less intermediate and severe renal insufficiencies (5.6% vs 13.3%). Conclusions Adequate perioperative fluid management and cytoprotection seem to be effective in protecting renal function. This allows the administration of higher intracavitary cisplatin doses without raising the rate of renal insufficiencies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MALIGNANT PLEURAL MESOTHELIOMA; EXTRAPLEURAL PNEUMONECTOMY; CISPLATIN CONCENTRATION; SODIUM THIOSULFATE; PHASE-II; AMIFOSTINE; PERFUSION; PLEURECTOMY/DECORTICATION; CYTOPROTECTION; NEPHROTOXICITY; cytoprotection; hyperthermic intrathoracic chemotherapy; hyperthermic intrathoracic chemotherapy; nephroprotection; renal insufficiency |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Thoraxchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2020 07:30 |
| Last Modified: | 24 Mar 2020 07:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25784 |
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