Stein-Thoeringer, C. K. and Nichols, K. B. and Lazrak, A. and Docampo, M. D. and Slingerland, A. E. and Slingerland, J. B. and Clurman, A. G. and Armijo, G. and Gomes, A. L. C. and Shono, Y. and Staffas, A. and da Silva, M. Burgos and Devlin, S. M. and Markey, K. A. and Bajic, D. and Pinedo, R. and Tsakmaklis, A. and Littmann, E. R. and Pastore, A. and Taur, Y. and Monette, S. and Arcila, M. E. and Pickard, A. J. and Maloy, M. and Wright, R. J. and Amoretti, L. A. and Fontana, E. and Pham, D. and Jamal, M. A. and Weber, D. and Sung, A. D. and Hashimoto, D. and Scheid, C. and Xavier, J. B. and Messina, J. A. and Romero, K. and Lew, M. and Bush, A. and Bohannon, L. and Hayasaka, K. and Hasegawa, Y. and Vehreschild, M. J. G. T. and Cross, J. R. and Ponce, D. M. and Perales, M. A. and Giralt, S. A. and Jenq, R. R. and Teshima, T. and Holler, E. and Chao, N. J. and Pamer, E. G. and Peled, J. U. and van den Brink, M. R. M. (2019) Lactose drives Enterococcus expansion to promote graft-versus-host disease. SCIENCE, 366 (6469). 1143-+. ISSN 0036-8075, 1095-9203
Full text not available from this repository. (Request a copy)Abstract
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence of enterococcal expansion, which was associated with graft-versus-host disease (GVHD) and mortality. We found that Enterococcus also expands in the mouse gastrointestinal tract after allo-HCT and exacerbates disease severity in gnotobiotic models. Enterococcus growth is dependent on the disaccharide lactose, and dietary lactose depletion attenuates Enterococcus outgrowth and reduces the severity of GVHD in mice. Allo-HCT patients carrying lactose-nonabsorber genotypes showed compromised clearance of postantibiotic Enterococcus domination. We report lactose as a common nutrient that drives expansion of a commensal bacterium that exacerbates an intestinal and systemic inflammatory disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VANCOMYCIN-RESISTANT ENTEROCOCCUS; CELL; MICROBIOME; BACTEREMIA; RISK; COLONIZATION; CHEMOTHERAPY; ANTIBIOTICS; COMMENSALS; DOMINATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 07:05 |
| Last Modified: | 06 Apr 2020 05:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25793 |
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