Shimoni, Avichai and Labopin, Myriam and Finke, Jurgen and Ciceri, Fabio and Deconinck, Eric and Kroger, Nicolaus and Gramatzki, Martin and Stelljes, Matthias and Blaise, Didier and Stoelzel, Friedrich and Chevallier, Patrice and Holler, Ernst and Fegueux, Nathalie and Mohty, Mohamad and Nagler, Arnon (2019) Donor selection for a second allogeneic stem cell transplantation in AML patients relapsing after a first transplant: a study of the Acute Leukemia Working Party of EBMT. BLOOD CANCER JOURNAL, 9: 88. ISSN 2044-5385,
Full text not available from this repository. (Request a copy)Abstract
Second allogeneic stem-cell transplantation (SCT2) is a therapeutic option for patients with AML relapsing after a first transplant. Prior studies have shown similar results after SCT2 from the same or different donor; however, there are limited data on second non-T-depleted haplo-identical transplant in this setting. We retrospectively analyzed SCT2 outcomes in 556 patients, median age 46 years, relapsing after first transplant given in CR1. Patients were divided into three groups based on SCT2 donor (donor2): same donor (n = 163, sib/sib-112, UD/UD-51), different matched donor (n = 305, sib/different sib-44, sib/UD-93, UD/different UD-168), or haplo-donor (n = 88, sib/haplo-45, UD/haplo-43). Two-year leukemia-free survival (LFS) rate after SCT2 was 23.5%, 23.7%, and 21.8%, respectively (P = 0.30). Multivariate analysis showed no effect of donor2 type on relapse: hazard ratio (HR) 0.89 (P = 0.57) and 1.11 (P = 0.68) for different donor and haplo-donor compared to same donor, respectively. However, donor2 did predict for non-relapse mortality (NRM) after SCT2: HR 1.21 (P = 0.50) and 2.08 (P = 0.03), respectively, and for LFS: HR 1.00 (P = 0.97) and 1.43 (P = 0.07), respectively. In conclusion, SCT2 with the same or different matched donor is associated with similar outcomes in patients with relapsed AML. Non-T-depleted haplo-identical transplant may be associated with higher NRM, similar relapse rate and with no better results in this setting.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HLA-HAPLOIDENTICAL DONORS; ACUTE MYELOID-LEUKEMIA; POSTTRANSPLANT CYCLOPHOSPHAMIDE; EUROPEAN-SOCIETY; RISK-FACTORS; BLOOD; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2020 10:23 |
| Last Modified: | 24 Mar 2020 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25824 |
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