Noordam, Raymond and Bos, Maxime M. and Wang, Heming and Winkler, Thomas W. and Bentley, Amy R. and Kilpelainen, Tuomas O. and de Vries, Paul S. and Sung, Yun Ju and Schwander, Karen and Cade, Brian E. and Manning, Alisa and Aschard, Hugues and Brown, Michael R. and Chen, Han and Franceschini, Nora and Musani, Solomon K. and Richard, Melissa and Vojinovic, Dina and Aslibekyan, Stella and Bartz, Traci M. and de las Fuentes, Lisa and Feitosa, Mary and Horimoto, Andrea R. and Ilkov, Marjan and Kho, Minjung and Kraja, Aldi and Li, Changwei and Lim, Elise and Liu, Yongmei and Mook-Kanamori, Dennis O. and Rankinen, Tuomo and Tajuddin, Salman M. and van der Spek, Ashley and Wang, Zhe and Marten, Jonathan and Laville, Vincent and Alver, Maris and Evangelou, Evangelos and Graff, Maria E. and He, Meian and Kuehnel, Brigitte and Lyytikainen, Leo-Pekka and Marques-Vidal, Pedro and Nolte, Ilja M. and Palmer, Nicholette D. and Rauramaa, Rainer and Shu, Xiao-Ou and Snieder, Harold and Weiss, Stefan and Wen, Wanqing and Yanek, Lisa R. and Adolfo, Correa and Ballantyne, Christie and Bielak, Larry and Biermasz, Nienke R. and Boerwinkle, Eric and Dimou, Niki and Eiriksdottir, Gudny and Gao, Chuan and Gharib, Sina A. and Gottlieb, Daniel J. and Haba-Rubio, Jose and Harris, Tamara B. and Heikkinen, Sami and Heinzer, Raphael and Hixson, James E. and Homuth, Georg and Ikram, M. Arfan and Komulainen, Pirjo and Krieger, Jose E. and Lee, Jiwon and Liu, Jingmin and Lohman, Kurt K. and Luik, Annemarie I. and Magi, Reedik and Martin, Lisa W. and Meitinger, Thomas and Metspalu, Andres and Milaneschi, Yuri and Nalls, Mike A. and O'Connell, Jeff and Peters, Annette and Peyser, Patricia and Raitakari, Olli T. and Reiner, Alex P. and Rensen, Patrick C. N. and Rice, Treva K. and Rich, Stephen S. and Roenneberg, Till and Rotter, Jerome I. and Schreiner, Pamela J. and Shikany, James and Sidney, Stephen S. and Sims, Mario and Sitlani, Colleen M. and Sofer, Tamar and Strauch, Konstantin and Swertz, Morris A. and Taylor, Kent D. and Uitterlinden, Andre G. and van Duijn, Cornelia M. and Voelzke, Henry and Waldenberger, Melanie and Wallance, Robert B. and van Dijk, Ko Willems and Yu, Caizheng and Zonderman, Alan B. and Becker, Diane M. and Elliott, Paul and Esko, Tonu and Gieger, Christian and Grabe, Hans J. and Lakka, Timo A. and Lehtimaki, Terho and North, Kari E. and Penninx, Brenda W. J. H. and Vollenweider, Peter and Wagenknecht, Lynne E. and Wu, Tangchun and Xiang, Yong-Bing and Zheng, Wei and Arnett, Donna K. and Bouchard, Claude and Evans, Michele K. and Gudnason, Vilmundur and Kardia, Sharon and Kelly, Tanika N. and Kritchevsky, Stephen B. and Loos, Ruth J. F. and Pereira, Alexandre C. and Province, Mike and Psaty, Bruce M. and Rotimi, Charles and Zhu, Xiaofeng and Amin, Najaf and Cupples, L. Adrienne and Fornage, Myriam and Fox, Ervin F. and Guo, Xiuqing and Gauderman, W. James and Rice, Kenneth and Kooperberg, Charles and Munroe, Patricia B. and Liu, Ching-Ti and Morrison, Alanna C. and Rao, Dabeeru C. and van Heemst, Diana and Redline, Susan (2019) Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. NATURE COMMUNICATIONS, 10: 5121. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; GENE-ENVIRONMENT INTERACTION; GAMMA-GLUTAMYL-TRANSFERASE; BODY-MASS INDEX; METABOLIC SYNDROME; DIURNAL RHYTHM; PLASMA-LIPIDS; RISK; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 07:29 |
| Last Modified: | 25 Mar 2020 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25837 |
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