Gontero, Paolo and Pisano, Francesca and Palou, Joan and Joniau, Steven and Albersen, Maarten and Colombo, Renzo and Briganti, Alberto and Pellucchi, Federico and Faba, Oscar Rodriguez and van Rhijn, Bas W. and van de Putte, Elies Fransen and Babjuk, Marko and Fritsche, Hanz Martin and Mayr, Roman and Albers, Peter and Niegisch, Gunter and Anract, Julien and Masson-Lecomte, Alexandra and De la Taille, Alexandre and Roupret, Morgan and Peyronnet, Benoit and Cai, Tomaso and Witjes, Alfred J. and Bruins, Max and Baniel, Jack and Mano, Roy and Lapini, Alberto and Sessa, Francesco and Irani, Jaques and Brausi, Maurizio and Stenzl, Arnulf and Karnes, Jeffrey R. and Scherr, Douglas and O'Malley, Padraic and Taylor, Benjamin and Shariat, Shahrokh F. and Black, Peter and Abdi, Hamidreza and Matveev, Vsevolod B. and Samuseva, Olga and Parekh, Dipen and Gonzalgo, Mark and Vetterlein, Malte W. and Aziz, Atiqullah and Fisch, Margit and Catto, James and Pang, Karl H. and Xylinas, Evanguelos and Rink, Michael (2019) Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases. WORLD JOURNAL OF UROLOGY. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
Purpose Conflicting evidence exists on the complication rates after cystectomy following previous radiation (pRTC) with only a few available series. We aim to assess the complication rate of pRTC for abdominal-pelvic malignancies. Methods Patients treated with radical cystectomy following any previous history of RT and with available information on complications for a minimum of 1 year were included. Univariable and multivariable logistic regression models were used to assess the relationship between the variable parameters and the risk of any complication. Results 682 patients underwent pRTC after a previous RT (80.5% EBRT) for prostate, bladder (BC), gynecological or other cancers in 49.1%, 27.4%, 9.8% and 12.9%, respectively. Overall, 512 (75.1%) had at least one post-surgical complication, classified as Clavien >= 3 in 29.6% and Clavien V in 2.9%. At least one surgical complication occurred in 350 (51.3%), including bowel leakage in 6.2% and ureteric stricture in 9.4%. A medical complication was observed in 359 (52.6%) patients, with UTI/pyelonephritis being the most common (19%), followed by renal failure (12%). The majority of patients (86%) received an incontinent urinary diversion. In multivariable analysis adjusted for age, gender and type of RT, patients treated with RT for bladder cancer had a 1.7 times increased relative risk of experiencing any complication after RC compared to those with RT for prostate cancer (p = 0.023). The type of diversion (continent vs non-continent) did not influence the risk of complications. Conclusion pRTC carries a high rate of major complications that dramatically exceeds the rates reported in RT-naive RCs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RADICAL CYSTECTOMY; BLADDER-CANCER; SALVAGE CYSTECTOMY; DIVERSION; MORTALITY; HISTORY; Bladder cancer; Radical cystectomy; Radiation therapy; Urinary diversion; Complications |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Apr 2020 07:55 |
| Last Modified: | 07 Apr 2020 07:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25859 |
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