Flamann, Cindy and Peter, Katrin and Kreutz, Marina and Bruns, Heiko (2019) Regulation of the Immune Balance During Allogeneic Hematopoietic Stem Cell Transplantation by Vitamin D. FRONTIERS IN IMMUNOLOGY, 10: 2586. ISSN 1664-3224,
Full text not available from this repository. (Request a copy)Abstract
One of the most promising therapeutic approaches for numerous hematological malignancies represents the allogeneic hematopoietic stem cell transplantation (allo-HSCT). One major complication is the development of the life-threatening graft-vs.-host disease (GvHD) which limits beneficial effects of graft-vs.-leukemia (GvL) responses during allo-HSCT. Strengthening GvL effects without induction of severe GvHD is essential to decrease the relapse rate after allo-HSCT. An interesting player in this context is vitamin D-3 since it has modulatory capacity in both preventing GvHD and boosting GvL responses. Current studies claim that vitamin D-3 induces an immunosuppressive environment by dendritic cell (DC)-dependent generation of regulatory T cells (Tregs). Since vitamin D-3 is known to support the antimicrobial defense by re-establishing the physical barrier as well as releasing defensins and antimicrobial peptides, it might also improve graft-vs.-infection (GvI) effects in patients. Beyond that, alloreactive T cells might be attenuated by vitamin D-3-mediated inhibition of proliferation and activation. Despite the inhibitory effects of vitamin D-3 on T cells, anti-tumor responses of GvL might be reinforced by vitamin D-3-triggered phagocytic activity and antibody-based immunotherapy. Therefore, vitamin D-3 treatment does not only lead to a shift from a pro-inflammatory toward a tolerogenic state but also promotes tumoricidal activity of immune cells. In this review we focus on vitamin D-3 and its immunomodulatory effects by enhancing anti-tumor activity while alleviating harmful allogeneic responses in order to restore the immune balance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; TOLEROGENIC DENDRITIC CELLS; PROSTATE-CANCER CELLS; 1,25-DIHYDROXYVITAMIN D-3; D-RECEPTOR; 1-ALPHA,25-DIHYDROXYVITAMIN D-3; D ANALOG; MYCOBACTERIUM-TUBERCULOSIS; DOWN-REGULATION; PEPTIDE LL-37; vitamin D; GvH; GvL; immune balance; macrophages; T cells; infection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2020 09:15 |
| Last Modified: | 23 Mar 2020 09:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25860 |
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