Bahr, Katharina and Zimmer, Stefanie and Springer, Erik and Fottner, Christian and Becker, Sven and Ernst, Benjamin P. and Matthias, Christoph and Kuenzel, Julian (2019) High-Grade Neuroendocrine Carcinoma of the Head and Neck: Human Papillomavirus Status and PD-L1 Expression. ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY, 81 (5-6). pp. 309-316. ISSN 0301-1569, 1423-0275
Full text not available from this repository. (Request a copy)Abstract
Background: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma represents an important subgroup of head and neck cancer, but HPV occurs also in the less common neuroendocrine carcinomas (NEC). The PD-1/PD-L1 pathway appears to be activated in pulmonary NEC and correlates with a higher mutation burden, but the potential of NEC to respond to checkpoint inhibitors is unknown to a large extent. Objectives: To determine the HPV status of NEC of the head and neck region and to investigate the expression of PD-1 and its ligands PD-L1 and PD-L2. Methods: Surgical tumor samples from 2006 to 2017 were analyzed. HPV status was determined by p16 immunohistochemistry (IHC) and multiplex PCR. IHC using the Cologne Score was performed for PD-1, PD-L1, and PD-L2. Results: Seven NEC tumor samples were analyzed, three of them showed HPV type 18. Expression of PD-1 and PD-L1 differed widely and showed no correlation to HPV status. IHC showed an overexpression of PD-L2 in most of the patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL LUNG-CANCER; PREDICTIVE BIOMARKER; PROGNOSTIC-FACTORS; OPEN-LABEL; OROPHARYNX; IMMUNOTHERAPY; PEMBROLIZUMAB; MULTICENTER; NIVOLUMAB; DISTINCT; Neuroendocrine carcinoma; Human papillomavirus; PD-L1; Head and neck; Immunotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 09:34 |
| Last Modified: | 06 Apr 2020 06:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25880 |
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