Knop, Stefan and Engelhardt, Monika and Liebisch, Peter and Meisner, Christoph and Holler, Ernst and Metzner, Bernd and Peest, Dietrich and Kaufmann, Martin and Bunjes, Donald and Straka, Christian and Fischer, Thomas and Sezer, Orhan and Hentrich, Marcus and Ostermann, Helmut and Bassermann, Florian and Hess, Georg and Hertenstein, Bernd and Freund, Mathias and Kropff, Martin and Schmidt, Christian A. and Wolf, Hans-Heinrich and Jung, Wolfram and Frickhofen, Norbert and Mielke, Stephan and Bargou, Ralf C. and Maschmeyer, Georg and Svaldi, Mirija and Langer, Christian H. and Gramatzki, Martin and Hebart, Holger and Kanz, Lothar and Einsele, Hermann and Sezer, O. and Doerken, B. and Gerecke, C. and Fuhrmann, S. and Ludwig, W. D. and Hertenstein, B. and Bormann, M. and Meyer, R. and Naumann, R. and Platzbecker, U. and Roellig, Ch and Roesler, W. and von Metzler, I and Martin, H. and Engelhardt, M. and Finke, J. and Truemper, L. and Jung, W. and Schmidt, Ch A. and Doelken, G. and Wolf, H. H. and Mueller, L. and Ligeti, K. and Kroeger, N. and Schilling, G. and Duerk, H. and Peest, D. and Ganser, A. and Pfreundschuh, M. and Sayer, H. and von Lilienfeld-Toal, M. and Muegge, L. O. and Bentz, M. and Gramatzki, M. and Brueggemann, M. and Fischer, T. and Wolleschak, D. and Hess, G. and Kropff, M. and Reusch, J. and Straka, C. and Ostermann, H. and Franke, D. and Peschel, C. and Dechow, T. and Bassermann, F. and Hentrich, M. and Wandt, H. and Schaefer-Eckart, K. and Metzner, B. and Maschmeyer, G. and Holler, E. and Hart, C. and Reichle, A. and Freund, M. and Boettcher, S. and Kahl, C. and Mergenthaler, H. G. and Aulitzky, W. and Kaufmann, M. and Greiner, J. and Heidemann, E. and Kanz, L. and Hebart, H. and Liebisch, P. and Bunjes, D. and Langer, C. and Frickhofen, N. and Einsele, H. and Knop, S. and Mielke, S. and Bargou, R. C. and Svaldi, M. (2019) Allogeneic transplantation in multiple myeloma: long-term follow-up and cytogenetic subgroup analysis. LEUKEMIA, 33 (11). pp. 2710-2719. ISSN 0887-6924, 1476-5551
Full text not available from this repository. (Request a copy)Abstract
This phase 3 trial compared tandem autologous stem cell transplantation (autoSCT) versus autoSCT followed by reduced-intensity conditioning allogeneic stem cell transplantation (auto/alloSCT) in patients with newly diagnosed multiple myeloma (MM) with deletion of (del) chromosome 13q (del13q). The availability/absence of a human leukocyte antigen-matched-related or matched-unrelated donor (MUD) determined the nature of the second SCT. The primary endpoint was progression-free survival (PFS) in the intention-to-treat population (n = 199). Auto/alloSCT was performed in 126 patients; 74 received MUD allografts. After 91 months median follow-up, median PFS with auto/allo versus tandem autoSCT was 34.5 versus 21.8 months (P = 0.003; adjusted hazard ratio 0.55, 95% confidence interval 0.36-0.84). Median overall survival (OS) was 70.2 versus 71.8 months (P = 0.856). Two-year non-relapse mortality with auto/allo versus tandem autoSCT was 14.3% versus 4.1% (P = 0.008). In patients harboring both del13q and del17p, median PFS and OS were 37.5 and 61.5 months with auto/allo (n = 19) versus 6.1 and 23.4 months with tandem autoSCT (n = 6) (P = 0.0002 and 0.032). Our findings suggest that auto/alloSCT significantly extends PFS versus tandem autoSCT in del13q MM, and indicate some survival benefit for first-line alloSCT in high-risk MM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; AUTOLOGOUS TRANSPLANTATION; PROGRESSION-FREE; IMPROVES; DONOR; MAINTENANCE; INDUCTION; SURVIVAL; DISEASE; TRIAL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2020 14:11 |
| Last Modified: | 24 Mar 2020 14:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/25921 |
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