Graf, Daniela and Weitkunat, Karolin and Doetsch, Andreas and Liebisch, Gerhard and Doering, Maik and Krueger, Ralf and Stoll, Dominic and Vatareck, Elisabeth and von Coburg, Elena and Loh, Gunnar and Watzl, Bernhard (2019) Specific Wheat Fractions Influence Hepatic Fat Metabolism in Diet-Induced Obese Mice. NUTRIENTS, 11 (10): 2348. ISSN , 2072-6643
Full text not available from this repository. (Request a copy)Abstract
Low whole grain consumption is a risk factor for the development of non-communicable diseases such as type 2 diabetes. Dietary fiber and phytochemicals are bioactive grain compounds, which could be involved in mediating these beneficial effects. These compounds are not equally distributed in the wheat grain, but are enriched in the bran and aleurone fractions. As little is known on physiological effects of different wheat fractions, the aim of this study was to investigate this aspect in an obesity model. For twelve weeks, C57BL/6J mice were fed high-fat diets (HFD), supplemented with one of four wheat fractions: whole grain flour, refined white flour, bran, or aleurone. The different diets did not affect body weight, however bran and aleurone decreased liver triglyceride content, and increased hepatic n-3 polyunsaturated fatty acid (PUFA) concentrations. Furthermore, lipidomics analysis revealed increased PUFA concentration in the lipid classes of phosphatidylcholine (PC), PC-ether, and phosphatidylinositol in the plasma of mice fed whole grain, bran, and aleurone supplemented diets, compared to refined white flour. Furthermore, bran, aleurone, and whole grain supplemented diets increased microbial alpha-diversity, but only bran and aleurone increased the cecal concentrations of short-chain fatty acids. The effects on hepatic lipid metabolism might thus at least partially be mediated by microbiota-dependent mechanisms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TANDEM MASS-SPECTROMETRY; HIGH-THROUGHPUT QUANTIFICATION; DOSE-RESPONSE METAANALYSIS; WHOLE-GRAIN; GUT MICROBIOTA; LIPID EXTRACTION; HEALTHY-ADULTS; BODY-WEIGHT; ACIDS; INFLAMMATION; wheat; whole grain; bran; aleurone; microbiota; SCFA; lipid metabolism; obesity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 09:32 |
| Last Modified: | 30 Mar 2020 09:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26050 |
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