Mueller-McNicoll, Michaela and Rossbach, Oliver and Hui, Jingyi and Medenbach, Jan (2019) Auto-regulatory feedback by RNA-binding proteins. JOURNAL OF MOLECULAR CELL BIOLOGY, 11 (10). pp. 930-939. ISSN 1674-2788, 1759-4685
Full text not available from this repository. (Request a copy)Abstract
tRNA-binding proteins (RBPs) are key regulators in post-transcriptional control of gene expression. Mutations that alter their activity or abundance have been implicated in numerous diseases such as neurodegenerative disorders and various types of cancer. This highlights the importance of RBP proteostasis and the necessity to tightly control the expression levels and activities of RBPs. In many cases, RBPs engage in an auto-regulatory feedback by directly binding to and influencing the fate of their own mRNAs, exerting control over their own expression. For this feedback control, RBPs employ a variety of mechanisms operating at all levels of post-transcriptional regulation of gene expression. Here we review RBP-mediated autogenous feedback regulation that either serves to maintain protein abundance within a physiological range (by negative feedback) or generates binary, genetic on/off switches important for e.g. cell fate decisions (by positive feedback).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESSENGER-RNA; THYMIDYLATE SYNTHASE; SPLICING FACTORS; POSTTRANSCRIPTIONAL CONTROL; MODULATES AUTOREGULATION; TRANSLATIONAL ACTIVATION; POLY(A) POLYMERASE; SEX DETERMINATION; CROSS-REGULATION; GENE-EXPRESSION; autogenous regulation; protein homeostasis; RNA-binding proteins; post-transcriptional regulation of gene expression |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2020 09:19 |
| Last Modified: | 24 Mar 2020 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26051 |
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