Raber, Jacob and Arzy, Shahar and Boulanger-Bertolus, Julie and Depue, Brendan and Haas, Haley E. and Hofmann, Stefan G. and Kangas, Maria and Kensinger, Elizabeth and Lowry, Christopher A. and Marusak, Hilary A. and Minnier, Jessica and Mouly, Anne-Marie and Muehlberger, Andreas and Norrholm, Seth Davin and Peltonen, Kirsi and Pinna, Graziano and Rabinak, Christine and Shiban, Youssef and Soreq, Hermona and van der Kooij, Michael A. and Lower, Leroy and Weingast, Leah. T. and Yamashita, Paula and Boutros, Sydney Weber (2019) Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 105. pp. 136-177. ISSN 0149-7634, 1873-7528
Full text not available from this repository. (Request a copy)Abstract
Fear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective experience of fear and the related biological processes involved in fear learning and memory. We first provide an overview of fear learning and memory in humans and animal models, encompassing the neurocircuitry and molecular mechanisms, the influence of genetic and environmental factors, and how fear learning paradigms have contributed to treatments for fear-related disorders, such as posttraumatic stress disorder. Current treatments as well as novel strategies, such as targeting the perisynaptic environment and use of virtual reality, are addressed. We review research on the subjective experience of fear and the role of autobiographical memory in fear-related disorders. We also discuss the gaps in our understanding of fear learning and memory, and the degree of consensus in the field. Lastly, the development of linguistic tools for assessments and treatment of fear learning and memory disorders is discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSTTRAUMATIC-STRESS-DISORDER; VIRTUAL-REALITY EXPOSURE; MEDIAL PREFRONTAL CORTEX; CORTICOTROPIN-RELEASING-FACTOR; EXCITATORY SYNAPTIC-TRANSMISSION; IMPROVES BEHAVIORAL DEFICITS; COGNITIVE BIAS MODIFICATION; TRAINING REDUCES DYSPHORIA; DEFENSIVE RAGE BEHAVIOR; LONG-TERM POTENTIATION; Fear; Virtual reality; Linguistics; Autobiography; Subjective fear; Neuroanatomy; Neuropharmacology |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Mar 2020 10:38 |
| Last Modified: | 25 Mar 2020 10:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26126 |
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