Liesche, Friederike and Ruf, Viktoria and Zoubaa, Saida and Kaletka, Gwendolyn and Rosati, Marco and Rubbenstroth, Dennis and Herden, Christiane and Goehring, Lutz and Wunderlich, Silke and Wachter, Miguel Frederic and Rieder, Georg and Lichtmannegger, Ines and Permanetter, Willibald and Heckmann, Josef G. and Angstwurm, Klemens and Neumann, Bernhard and Maerkl, Bruno and Haschka, Stefan and Niller, Hans-Helmut and Schmidt, Barbara and Jantsch, Jonathan and Brochhausen, Christoph and Schlottau, Kore and Ebinger, Arnt and Hemmer, Bernhard and Riemenschneider, Markus J. and Herms, Jochen and Beer, Martin and Matiasek, Kaspar and Schlegel, Juergen (2019) The neuropathology of fatal encephalomyelitis in human Borna virus infection. ACTA NEUROPATHOLOGICA, 138 (4). pp. 653-665. ISSN 0001-6322, 1432-0533
Full text not available from this repository. (Request a copy)Abstract
After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection of BoDV-1-typical eosinophilic, spherical intranuclear Joest-Degen inclusion bodies. While the composition of histopathological changes was constant, the inflammatory distribution pattern varied interindividually, affecting predominantly the basal nuclei in two patients, hippocampus in one patient, whereas two patients showed a more diffuse distribution. By immunohistochemistry and RNA in situ hybridization, BoDV-1 was detected in all examined brain tissue samples. Furthermore, infection of the peripheral nervous system was observed. This study aims at raising awareness to human bornavirus encephalitis as differential diagnosis in lymphocytic sclerosing panencephalomyelitis. A higher attention to human BoDV-1 infection by health professionals may likely increase the detection of more cases and foster a clearer picture of the disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE VIRUS; EXPRESSION; RESERVOIR; GERMANY; BRAINS; SHREWS; CELLS; MICE; Virus; Bornavirus; Borna disease virus (BoDV-1); Zoonosis; Encephalitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2020 12:56 |
| Last Modified: | 26 Mar 2020 12:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26148 |
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