Indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2019

Duarte, Rafael F. and Labopin, Myriam and Bader, Peter and Basak, Grzegorz W. and Bonini, Chiara and Chabannon, Christian and Corbacioglu, Selim and Dreger, Peter and Dufour, Carlo and Genneryl, Andrew R. and Kuball, Juergen and Lankester, Arjan C. and Lanza, Francesco and Montoto, Silvia and Nagler, Arnon and de Latour, Regis Peffault and Snowden, John A. and Styczynski, Jan and Yakoub-Agha, Ibrahim and Kroeger, Nicolaus and Mohty, Mohamad and Albert, Michael and Alexander, Tobias and Averbuch, Dina and Baron, Frederic and Bazarbachi, Eli and Beksac, Meral and Brissot, Eolia and Bug, Gesine and Cesaro, Simone and Chalandon, Yves and Ciceri, Fabo and Czerw, Tomasz and Dazzi, Francesco and Esteve, Jordi and Fleischhauer, Katarina and Garderet, Laurent and Giebel, Sebastian and Gil, Lidia and Gilleece, Maria and Gorin, Norbert-Claude and Hayden, Patrick and Halter, Jorg and Hernandez Boluda, Juan C. and Hudecek, Michael and Kleinschmidt, Katharina and Kenyon, Michelle and Koenecke, Christian and Locatelli, Franco and Malard, Florent and McLornan, Donal and Mikulska, Malgorzata and Murray, John and Onida, Francesco and Pedrazzoli, Paolo and Penack, Olaf and Peric, Zinaida and Risitano, Antonio and Robin, Marie and Robinson, Steve and Ruggeri, Annalisa and Sanz, Jaime and Savani, Bipin and Schetelig, Johannes and Schied, Christof and Schmid, Christoph and Schoemans, Helene and Schonland, Stefan and Sharrack, Basil and Shouval, Roni and Spyridonidis, Alexandros and Toubert, Antoine and Tourniac, Olivier and Urbano-Ispizua, Alvaro and Vago, Luca and van Gelder, Michel and Verhoeven, Bregje and Versluis, Jurjen and Wietten, Lotte and Willasch, Andre (2019) Indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2019. BONE MARROW TRANSPLANTATION, 54 (10). pp. 1525-1552. ISSN 0268-3369, 1476-5365

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Abstract

This is the seventh special EBMT report on the indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders. Our aim is to provide general guidance on transplant indications according to prevailing clinical practice in EBMT countries and centres. In order to inform patient decisions, these recommendations must be considered together with the risk of the disease, the risk of the transplant procedure and the results of non-transplant strategies. In over two decades since the first report, the EBMT indications manuscripts have incorporated changes in transplant practice coming from scientific and technical developments in the field. In this same period, the establishment of JACIE accreditation has promoted high quality and led to improved outcomes of patient and donor care and laboratory performance in transplantation and cellular therapy. An updated report with operating definitions, revised indications and an additional set of data with overall survival at 1 year and non-relapse mortality at day 100 after transplant in the commonest standard-of-care indications is presented. Additional efforts are currently underway to enable EBMT member centres to benchmark their risk-adapted outcomes as part of the Registry upgrade Project 2020 against national and/or international outcome data.

Item Type: Article
Uncontrolled Keywords: HIGH-DOSE CHEMOTHERAPY; ACUTE LYMPHOBLASTIC-LEUKEMIA; CORD-BLOOD TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; SEVERE APLASTIC-ANEMIA; UNRELATED DONOR TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; LYMPHOMA WORKING PARTY; LONG-TERM OUTCOMES;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation
Depositing User: Dr. Gernot Deinzer
Date Deposited: 26 Mar 2020 13:07
Last Modified: 26 Mar 2020 13:07
URI: https://pred.uni-regensburg.de/id/eprint/26153

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