Dozio, Elena and Vianello, Elena and Malavazos, Alexis E. and Tacchini, Lorenza and Schmitz, Gerd and Iacobellis, Gianluca and Romanelli, Massimiliano M. Corsi (2019) Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: A target to modulate cardiovascular risk? INTERNATIONAL JOURNAL OF CARDIOLOGY, 292. pp. 218-224. ISSN 0167-5273, 1874-1754
Full text not available from this repository. (Request a copy)Abstract
Background: Epicardial adipose tissue (EAT) is a risk factor for cardiovascular diseases. Glucagon-like peptide 1 analogs (GLP-1A) may have beneficial cardiovascular effects and reduce EAT, possibly throughout targeting GLP-1 receptor (GLP-1R). Nevertheless, the role of EAT GLP-1R, GLP-2R and their interplay with EAT genes involved in adipogenesis and fatty acid (FA) metabolism are unknown. We analyzedwhether EAT transcriptome is related to GLP-1R/GLP-2R gene expression, and GLP-1/GLP-2 plasma levels in coronary artery disease patients (CAD). Methods: EAT was collected from 17 CAD patients undergoing CABG for microarray analysis of GLP-1R, GLP-2R and genes involved in FA metabolism and adipogenesis. EAT thickness was measured by echocardiography. GLP-1 and GLP-2 levels were quantified by ELISA in CAD and healthy subjects (CTR). Results: EAT GLP-1Rwas directly correlated with genes promoting beta-oxidation andwhite-to-brown adipocyte differentiation, and inversely with pro-adipogenic genes. GLP-2R was positively correlated with genes involved in adipogenesis and lipid synthesis, and inversely with genes promoting beta-oxidation. GLP-1 and GLP-2 levels were higher in CAD than CTR and in patients with greater EAT thickness. Conclusions: GLP-1 analogs may target EAT GLP-1R and therefore reduce local adipogenesis, improve fat utilization and induce brown fat differentiation. As EAT lies in direct contiguity to myocardium and coronary arteries, the beneficial effects of GLP-1 activation may extent to the heart. The increased levels of circulating GLP-1 and GLP-2 and EAT GLP-2R may be compensatory mechanisms related to CAD and also EAT expansion, but the meaning of these observations needs to be further investigated. (C) 2019 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLUCAGON-LIKE PEPTIDE-1; SOLUBILIZED MEMBRANES; LIRAGLUTIDE; DISEASE; OBESITY; EXPRESSION; PATHWAYS; AMIDE; Epicardial adipose tissue; Epicardial fat; GLP-1 receptor; GLP-2 receptor; Fatty acid oxidation; White-to-brown fat differentiation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Mar 2020 08:24 |
| Last Modified: | 27 Mar 2020 08:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26198 |
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