Wagels, Lisa and Votinov, Mikhail and Kellermann, Thilo and Konzok, Julian and Jung, Sonja and Montag, Christian and Schneider, Frank and Eisert, Albrecht and Beyer, Cordian and Habel, Ute (2019) Exogenous testosterone and the monoamine-oxidase A polymorphism influence anger, aggression and neural responses to provocation in males. NEUROPHARMACOLOGY, 156: UNSP 10749. ISSN 0028-3908, 1873-7064
Full text not available from this repository. (Request a copy)Abstract
Testosterone and the monoamine oxidase-A (MAOA) polymorphism are potential neuromodulators for aggression. By acting on similar brain circuits, they might interactively influence human behavior. The current study investigates the causal role of testosterone on aggression-related brain activity and the potential interaction with the MAOA polymorphism. In a double-blind process, 93 healthy males received a testosterone or placebo gel. In an fMRI session, participants performed a Taylor aggression paradigm in which they received provoking feedback and could afterwards decide how aggressively they would react. Testosterone and cortisol levels as well as subjective anger were assessed prior and after the task. Circulating testosterone levels were higher in carriers of the long compared to the short MAOA allele. An interaction of the MAOA polymorphism and testosterone administration was identified in the cuneus, where short allele carriers in the placebo group showed diminished activity in the decision period. Task-related anger was significantly higher in this group. Overall, a mesocorticolimbic network was implicated in processing of high versus low provoking feedback, and core hubs of the default mode network were implicated in the subsequent decision after high versus low provocation. Testosterone administration increased activation in this network. The data provides evidence for an interaction of the MAOA polymorphism and exogenous testosterone on anger and suggests that interactive effects on the brain signal could underlie differential emotional reactivity. The increased default mode activation in the testosterone group suggests an enhanced engagement of social cognition related regions possibly supporting responsivity towards social provocation. This article is part of the Special Issue entitled 'Current status of the neurobiology of aggression and impulsivity'.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEFAULT MODE NETWORK; SIGNAL-TO-NOISE; ENDOGENOUS TESTOSTERONE; MAOA GENOTYPE; REACTIVE AGGRESSION; SOCIAL AGGRESSION; AMYGDALA ACTIVITY; GENETIC RISK; HEALTHY-MEN; MECHANISMS; Hormones; Genetics; Anger; Default mode network; Cuneus; fMRI |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 05:47 |
| Last Modified: | 30 Mar 2020 05:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26249 |
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